Journal article
Sleep architecture in insomniacs with severe benzodiazepine abuse.
- Manconi M Sleep and Epilepsy Center, Neurocenter of the Southern Switzerland, Civic Hospital of Lugano, Lugano, Switzerland. Electronic address: mauro.manconi@eoc.ch.
- Ferri R Sleep Research Centre, Department of Neurology I.C., Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Italy.
- Miano S Sleep and Epilepsy Center, Neurocenter of the Southern Switzerland, Civic Hospital of Lugano, Lugano, Switzerland.
- Maestri M Sleep and Epilepsy Center, Neurocenter of the Southern Switzerland, Civic Hospital of Lugano, Lugano, Switzerland; Department of Neurosciences, Neurological Clinic, University of Pisa, Italy.
- Bottasini V Sleep Disorders Center, Vita-Salute San Raffaele University, Milan, Italy.
- Zucconi M Sleep Disorders Center, Vita-Salute San Raffaele University, Milan, Italy.
- Ferini-Strambi L Sleep Disorders Center, Vita-Salute San Raffaele University, Milan, Italy.
- 2017-04-12
Published in:
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. - 2017
Benzodiazepine
Cyclic alternating pattern
Insomnia
Adult
Benzodiazepines
Brain Waves
Case-Control Studies
Female
Humans
Male
Middle Aged
Prescription Drug Overuse
Sleep Initiation and Maintenance Disorders
Sleep, REM
English
OBJECTIVE
Benzodiazepines (BZDs) are the most commonly prescribed compounds in insomnia. A long-term of BZDs use may cause dependence and abuse. The aim of this study was to evaluate sleep architecture and microstructure (in terms of cyclic alternating pattern - CAP - analysis and of sleep EEG power spectral analysis) in a group of long-term users of high doses of BZDs for their primary chronic insomnia.
METHODS
Twenty patients consecutively admitted at the Sleep Centre for drug discontinuation and 13 matched healthy controls underwent a full nocturnal video-polysomnographic recording, after one adaptation night.
RESULTS
Significant differences were found in time in bed, REM sleep latency and sleep stage 1% which were increased in patients compared to controls, while CAP rate was dramatically decreased. During NREM sleep, patients showed a clear decrease in the relative power of delta band.
CONCLUSIONS
Our data demonstrate that in adults with chronic insomnia, long-term use of high doses of BZDs induces a severe disruption of sleep microstructure, while sleep architecture seems to be much less affected.
SIGNIFICANCE
The long term use of high doses of BZDs for chronic insomnia induces a marked depression of slow wave activity and of its physiological instability.
Benzodiazepines (BZDs) are the most commonly prescribed compounds in insomnia. A long-term of BZDs use may cause dependence and abuse. The aim of this study was to evaluate sleep architecture and microstructure (in terms of cyclic alternating pattern - CAP - analysis and of sleep EEG power spectral analysis) in a group of long-term users of high doses of BZDs for their primary chronic insomnia.
METHODS
Twenty patients consecutively admitted at the Sleep Centre for drug discontinuation and 13 matched healthy controls underwent a full nocturnal video-polysomnographic recording, after one adaptation night.
RESULTS
Significant differences were found in time in bed, REM sleep latency and sleep stage 1% which were increased in patients compared to controls, while CAP rate was dramatically decreased. During NREM sleep, patients showed a clear decrease in the relative power of delta band.
CONCLUSIONS
Our data demonstrate that in adults with chronic insomnia, long-term use of high doses of BZDs induces a severe disruption of sleep microstructure, while sleep architecture seems to be much less affected.
SIGNIFICANCE
The long term use of high doses of BZDs for chronic insomnia induces a marked depression of slow wave activity and of its physiological instability.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.clinph.2017.03.009
- PMID 28399441
- Persistent URL
- https://folia.unifr.ch/global/documents/279181
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