Journal article

Multi-ethnic genome-wide association study for atrial fibrillation.

  • Roselli C Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Chaffin MD Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Weng LC Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Aeschbacher S University Hospital Basel, Basel, Switzerland.
  • Ahlberg G Laboratory for Molecular Cardiology, The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Albert CM Divisions of Preventive and Cardiovascular Medicine, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.
  • Almgren P Department of Clinical Sciences, Lund University, Malmo, Sweden.
  • Alonso A Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Anderson CD Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Aragam KG Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Arking DE McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Barnard J Departments of Cardiovascular Medicine, Cellular and Molecular Medicine, Molecular Cardiology, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
  • Bartz TM Cardiovascular Health Research Unit, Departments of Medicine and Biostatistics, University of Washington, Seattle, WA, USA.
  • Benjamin EJ NHLBI and Boston University's Framingham Heart Study, Framingham, MA, USA.
  • Bihlmeyer NA Predoctoral Training Program in Human Genetics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Bis JC Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Bloom HL Division of Cardiology, Emory University and Atlanta VA Medical Center, Atlanta, GA, USA.
  • Boerwinkle E Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
  • Bottinger EB The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Brody JA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Calkins H Johns Hopkins University, Baltimore, MD, USA.
  • Campbell A Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Cappola TP Penn Cardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Carlquist J Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.
  • Chasman DI Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Chen LY Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
  • Chen YI Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Choi EK Seoul National University Hospital, Seoul, Korea.
  • Choi SH Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Christophersen IE Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Chung MK Departments of Cardiovascular Medicine, Cellular and Molecular Medicine, Molecular Cardiology, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
  • Cole JW Baltimore Veterans Affairs Medical Center, Department of Neurology, Baltimore, MD, USA.
  • Conen D University Hospital Basel, Basel, Switzerland.
  • Cook J Department of Biostatistics, University of Liverpool, Liverpool, UK.
  • Crijns HJ Maastricht University Medical Center+ and Cardiovascular Research Institute Maastricht, Department of Cardiology, Maastricht, The Netherlands.
  • Cutler MJ Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.
  • Damrauer SM Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Daniels BR Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Darbar D University of Illinois Chicago, Chicago, IL, USA.
  • Delgado G Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
  • Denny JC Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Dichgans M Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • Dörr M Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
  • Dudink EA Maastricht University Medical Center+ and Cardiovascular Research Institute Maastricht, Department of Cardiology, Maastricht, The Netherlands.
  • Dudley SC Cardiovascular Division and Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, USA.
  • Esa N University of Massachusetts Medical School Worcester, Worcester, MA, USA.
  • Esko T Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Eskola M Heart Center, Department of Cardiology, Tampere University Hospital, Finland and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Fatkin D Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
  • Felix SB Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
  • Ford I Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK.
  • Franco OH Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Geelhoed B Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Grewal RP Dept. of Neuroscience, Saint Francis Medical Center, Trenton, NJ, USA.
  • Gudnason V Icelandic Heart Association, Kopavogur, Iceland.
  • Guo X Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Gupta N Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Gustafsson S Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Gutmann R Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA.
  • Hamsten A Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
  • Harris TB Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.
  • Hayward C MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Heckbert SR Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Hernesniemi J Heart Center, Department of Cardiology, Tampere University Hospital, Finland and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Hocking LJ Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
  • Hofman A Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Horimoto ARVR Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil.
  • Huang J Boston VA Research Institute, Inc., Boston, MA, USA.
  • Huang PL Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
  • Huffman J MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Ingelsson E Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Ipek EG Johns Hopkins University, Baltimore, MD, USA.
  • Ito K Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Jimenez-Conde J Department of Neurology, Neurovascular Research Group IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Médiques), Barcelona, Spain.
  • Johnson R Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
  • Jukema JW Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Kääb S Department of Medicine I, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.
  • Kähönen M Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Kamatani Y Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Kane JP Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
  • Kastrati A DZHK (German Centre for Cardiovascular Research), partner site: Munich Heart Alliance, Munich, Germany.
  • Kathiresan S Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Katschnig-Winter P Department of Neurology, Medical University of Graz, Graz, Austria.
  • Kavousi M Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Kessler T Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, Germany.
  • Kietselaer BL Maastricht University Medical Center+ and Cardiovascular Research Institute Maastricht, Department of Cardiology, Maastricht, The Netherlands.
  • Kirchhof P Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
  • Kleber ME Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
  • Knight S Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.
  • Krieger JE Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil.
  • Kubo M RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Launer LJ Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.
  • Laurikka J Department of Cardio-Thoracic Surgery, Heart Center, Tampere University Hospital, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Lehtimäki T Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Leineweber K Dept. Disease Genomics, Bayer, Wuppertal, Germany.
  • Lemaitre RN Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Li M Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
  • Lim HE Korea University Guro Hospital, Seoul, Korea.
  • Lin HJ Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Lin H NHLBI and Boston University's Framingham Heart Study, Framingham, MA, USA.
  • Lind L Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
  • Lindgren CM Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Lokki ML Transplantation Laboratory, Medicum, University of Helsinki, Helsinki, Finland.
  • London B Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA.
  • Loos RJF The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Low SK Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Lu Y The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Lyytikäinen LP Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Macfarlane PW Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
  • Magnusson PK Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Mahajan A Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Malik R Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • Mansur AJ Heart Institute, University of São Paulo, São Paulo, Brazil.
  • Marcus GM Division of Cardiology, University of California, San Francisco, San Francisco, California, USA.
  • Margolin L Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Margulies KB Penn Cardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • März W Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
  • McManus DD University of Massachusetts Medical School Worcester, Worcester, MA, USA.
  • Melander O Department of Internal Medicine, Clinical Sciences, Lund University, Malmo, Sweden.
  • Mohanty S Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA.
  • Montgomery JA Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Morley MP Penn Cardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Morris AP Department of Biostatistics, University of Liverpool, Liverpool, UK.
  • Müller-Nurasyid M Department of Medicine I, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.
  • Natale A Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA.
  • Nazarian S University of Pennsylvania, Philadelphia, PA, USA.
  • Neumann B Department of Medicine I, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.
  • Newton-Cheh C Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Niemeijer MN Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Nikus K Heart Center, Department of Cardiology, Tampere University Hospital, Finland and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Nilsson P Department of Clinical Sciences, Lund University and Skåne University Hospital, Malmo, Sweden.
  • Noordam R Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
  • Oellers H Atrial Fibrillation NETwork, Muenster, Germany.
  • Olesen MS Laboratory for Molecular Cardiology, The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Orho-Melander M Department of Clinical Sciences, Lund University, Malmo, Sweden.
  • Padmanabhan S Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
  • Pak HN Yonsei University Health System, Seoul, Korea.
  • Paré G Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
  • Pedersen NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Pera J Department of Neurology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.
  • Pereira A Laboratory of Genetics and Molecular Biology, Heart Institute, University of São Paulo, São Paulo, Brazil.
  • Porteous D Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Psaty BM Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
  • Pulit SL Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Pullinger CR Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
  • Rader DJ Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Refsgaard L Laboratory for Molecular Cardiology, The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Ribasés M Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Ridker PM Divisions of Preventive and Cardiovascular Medicine, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.
  • Rienstra M Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Risch L University Institute of Clinical Chemistry, University of Bern, Bern, Switzerland.
  • Roden DM Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Rosand J Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Rosenberg MA Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Rost N Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Rotter JI Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Saba S Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Sandhu RK Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada.
  • Schnabel RB Department of General and Interventional Cardiology, University Heart Centre Hamburg, Hamburg, Germany.
  • Schramm K Department of Medicine I, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.
  • Schunkert H DZHK (German Centre for Cardiovascular Research), partner site: Munich Heart Alliance, Munich, Germany.
  • Schurman C The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Scott SA Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Seppälä I Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
  • Shaffer C Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Shah S Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
  • Shalaby AA Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Shim J Korea University Anam Hospital, Seoul, Korea.
  • Shoemaker MB Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Siland JE Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Sinisalo J Heart and Lung Center HUS, Helsinki University Central Hospital, Helsinki, Finland.
  • Sinner MF Department of Medicine I, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.
  • Slowik A Department of Neurology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.
  • Smith AV Icelandic Heart Association, Kopavogur, Iceland.
  • Smith BH Division of Population Health Sciences, University of Dundee, Dundee, UK.
  • Smith JG Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Smith JD Departments of Cardiovascular Medicine, Cellular and Molecular Medicine, Molecular Cardiology, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
  • Smith NL Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Soliman EZ Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston Salem, NC, USA.
  • Sotoodehnia N Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA.
  • Stricker BH Department of Epidemiology and Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Sun A Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
  • Sun H Departments of Cardiovascular Medicine, Cellular and Molecular Medicine, Molecular Cardiology, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
  • Svendsen JH Laboratory for Molecular Cardiology, The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Tanaka T Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan.
  • Tanriverdi K University of Massachusetts Medical School Worcester, Worcester, MA, USA.
  • Taylor KD Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Teder-Laving M Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Teumer A DZHK (German Centre for Cardiovascular Research), partner site: Greifswald, Greifswald, Germany.
  • Thériault S Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
  • Trompet S Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Tucker NR Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Tveit A Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Drammen, Norway.
  • Uitterlinden AG Department of Epidemiology and Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Van Der Harst P Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Van Gelder IC Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Van Wagoner DR Departments of Cardiovascular Medicine, Cellular and Molecular Medicine, Molecular Cardiology, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
  • Verweij N Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Vlachopoulou E Transplantation Laboratory, Medicum, University of Helsinki, Helsinki, Finland.
  • Völker U DZHK (German Centre for Cardiovascular Research), partner site: Greifswald, Greifswald, Germany.
  • Wang B Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Weeke PE Laboratory for Molecular Cardiology, The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Weijs B Maastricht University Medical Center+ and Cardiovascular Research Institute Maastricht, Department of Cardiology, Maastricht, The Netherlands.
  • Weiss R Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA.
  • Weiss S DZHK (German Centre for Cardiovascular Research), partner site: Greifswald, Greifswald, Germany.
  • Wells QS Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Wiggins KL Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Wong JA Division of Cardiology, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Woo D University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Worrall BB Departments of Neurology and Public Health Science, University of Virginia Health System, Charlottesville, VA, USA.
  • Yang PS Yonsei University Health System, Seoul, Korea.
  • Yao J Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Yoneda ZT Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Zeller T Department of General and Interventional Cardiology, University Heart Centre Hamburg, Hamburg, Germany.
  • Zeng L Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, Germany.
  • Lubitz SA Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Lunetta KL NHLBI and Boston University's Framingham Heart Study, Framingham, MA, USA.
  • Ellinor PT Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. ellinor@mgh.harvard.edu.
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  • 2018-06-13
Published in:
  • Nature genetics. - 2018
English Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
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