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Intravenous thrombolysis and platelet count.
Journal article

Intravenous thrombolysis and platelet count.

  • Gensicke H From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland. henrik.gensicke@usb.ch.
  • Al Sultan AS From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Strbian D From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Hametner C From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Zinkstok SM From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Moulin S From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Bill O From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Zini A From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Padjen V From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Kägi G From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Pezzini A From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Seiffge DJ From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Traenka C From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Räty S From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Amiri H From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Zonneveld TP From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Lachenmeier R From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Polymeris A From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Roos YB From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Gumbinger C From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Jovanovic DR From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Curtze S From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Sibolt G From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Vandelli L From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Ringleb PA From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Leys D From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Cordonnier C From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Michel P From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Lyrer PA From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Peters N From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Tatlisumak T From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Nederkoorn PJ From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
  • Engelter ST From the Stroke Center and Department of Neurology (H.G., D.J.S., C.T., R.L., A. Polymeris, P.A.L., N.P., S.T.E.), University Hospital Basel and University of Basel, Switzerland; Department of Clinical Neurosciences (H.G., A.S.A.S.), University of Calgary, Alberta, Canada; Department of Neurology (D.S., S.R., S.C., G.S., T.T.), Helsinki University Central Hospital, Finland; Department of Neurology (C.H., H.A., C.G., P.A.R.), University Hospital Heidelberg, Germany; Department of Neurology (S.M.Z., T.P.Z., Y.B.R., P.J.N.), Academic Medical Center, Amsterdam, the Netherlands; University Lille (S.M., D.L., C.C.), Inserm, CHU Lille, U1171-Degenerative & Vascular Cognitive Disorders, France; Department of Neurology (O.B., P.M.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; Stroke Unit (A.Z., L.V.), Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, AUSL Modena, Italy; Neurology Clinic (V.P., D.R.J.), Clinical Centre of Serbia, Belgrade; Department of Neurology (G.K.), Kantonsspital St. Gallen, Switzerland; Department of Clinical and Experimental Sciences (A. Pezzini), Neurology Clinic, University of Brescia, Italy; Medical Faculty (D.R.J.), University of Belgrade, Serbia; Institute of Neuroscience and Physiology (T.T.), Sahlgrenska Academy at University of Gothenburg; Department of Neurology (T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Switzerland.
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  • 2018-01-26
Published in:
  • Neurology. - 2018
Administration, Intravesical
Aged
Aged, 80 and over
Female
Hemorrhage
Humans
Male
Middle Aged
Platelet Count
Prospective Studies
Registries
Risk Factors
Stroke
Survival Analysis
Thrombocytopenia
Thrombocytosis
Thrombolytic Therapy
English OBJECTIVE
To study the effect of platelet count (PC) on bleeding risk and outcome in stroke patients treated with IV thrombolysis (IVT) and to explore whether withholding IVT in PC < 100 × 109/L is supported.


METHODS
In this prospective multicenter, IVT register-based study, we compared PC with symptomatic intracranial hemorrhage (sICH; Second European-Australasian Acute Stroke Study [ECASS II] criteria), poor outcome (modified Rankin Scale score 3-6), and mortality at 3 months. PC was used as a continuous and categorical variable distinguishing thrombocytopenia (<150 × 109/L), thrombocytosis (>450 × 109/L), and normal PC (150-450 × 109/L [reference group]). Moreover, PC < 100 × 109/L was compared to PC ≥ 100 × 109/L. Unadjusted and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) from the logistic regression models were calculated.


RESULTS
Among 7,533 IVT-treated stroke patients, 6,830 (90.7%) had normal PC, 595 (7.9%) had thrombocytopenia, and 108 (1.4%) had thrombocytosis. Decreasing PC (every 10 × 109/L) was associated with increasing risk of sICH (ORadjusted 1.03, 95% CI 1.02-1.05) but decreasing risk of poor outcome (ORadjusted 0.99, 95% CI 0.98-0.99) and mortality (ORadjusted 0.98, 95% CI 0.98-0.99). The risk of sICH was higher in patients with thrombocytopenic than in patients with normal PC (ORadjusted 1.73, 95% CI 1.24-2.43). However, the risk of poor outcome (ORadjusted 0.89, 95% CI 0.39-1.97) and mortality (ORadjusted 1.09, 95% CI 0.83-1.44) did not differ significantly. Thrombocytosis was associated with mortality (ORadjusted 2.02, 95% CI 1.21-3.37). Forty-four (0.3%) patients had PC < 100 × 109/L. Their risks of sICH (ORunadjusted 1.56, 95% CI 0.48-5.07), poor outcome (ORadjusted 1.63, 95% CI 0.82-3.24), and mortality (ORadjusted 1.38, 95% CI 0.64-2.98) did not differ significantly from those of patients with PC ≥ 100 × 109/L.


CONCLUSION
Lower PC was associated with increased risk of sICH, while higher PC indicated increased mortality. Our data suggest that PC modifies outcome and complications in individual patients, while withholding IVT in all patients with PC < 100 × 109/L is challenged.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/273326
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