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Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells.

  • Satoh R Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan.
  • Kakugawa K Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan.
  • Yasuda T Laboratory for Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokoham, Japan.
  • Yoshida H Laboratory for Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokoham, Japan.
  • Sibilia M Department of Medicine I, Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
  • Katsura Y Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan.
  • Levi B Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
  • Abramson J Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
  • Koseki Y Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Koseki H Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • van Ewijk W Department of Molecular Cell Biology and Department of Immunology, Leiden University Medical Center, RA Leiden, the Netherlands.
  • Hollander GA Laboratory of Pediatric Immunology, Center for Biomedicine, University of Basel, and the University Children's Hospital, Basel, Switzerland.
  • Kawamoto H Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan.
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  • 2016-01-21
Published in:
  • PLoS genetics. - 2016
Animals
Cell Differentiation
Embryonic Development
Epithelial Cells
ErbB Receptors
Flow Cytometry
Gene Expression Regulation, Developmental
Mice
STAT3 Transcription Factor
Signal Transduction
T-Lymphocytes
Thymocytes
Thymus Gland
English Thymic medullary regions are formed in neonatal mice as islet-like structures, which increase in size over time and eventually fuse a few weeks after birth into a continuous structure. The development of medullary thymic epithelial cells (TEC) is dependent on NF-κB associated signaling though other signaling pathways may contribute. Here, we demonstrate that Stat3-mediated signals determine medullary TEC cellularity, architectural organization and hence the size of the medulla. Deleting Stat3 expression selectively in thymic epithelia precludes the postnatal enlargement of the medulla retaining a neonatal architecture of small separate medullary islets. In contrast, loss of Stat3 expression in cortical TEC neither affects the cellularity or organization of the epithelia. Activation of Stat3 is mainly positioned downstream of EGF-R as its ablation in TEC phenocopies the loss of Stat3 expression in these cells. These results indicate that Stat3 meditated signal via EGF-R is required for the postnatal development of thymic medullary regions.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/273298
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