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SnAP-eX Reagents for the Synthesis of Exocyclic 3-Amino- and 3-Alkoxypyrrolidines and Piperidines from Aldehydes.

  • Luescher MU Laboratorium für Organische Chemie, ETH Zürich , HCI F 315, Vladimir Prelog Weg 3, 8093 Zürich, Switzerland.
  • Bode JW Laboratorium für Organische Chemie, ETH Zürich , HCI F 315, Vladimir Prelog Weg 3, 8093 Zürich, Switzerland.
  • 2016-05-19
Published in:
  • Organic letters. - 2016
Physical and Theoretical Chemistry
Organic Chemistry
Biochemistry
English SnAP-eX (tin amine protocol, exocyclic heteroatoms) reagents allow the single-step transformation of aldehydes and ketones into 2,3-disubstituted pyrrolidines and piperidines containing exocyclic amine or alkoxy groups. These saturated N-heterocycles are of importance in modern drug discovery approaches and are prepared in moderate yields using an operationally simple protocol that is compatible with a range of functional groups and heterocyclic aldehydes.
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  • English
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green
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https://folia.unifr.ch/global/documents/272505
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