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Secondary structure of a mitochondrial signal peptide in lipid bilayer membranes.
Journal article

Secondary structure of a mitochondrial signal peptide in lipid bilayer membranes.

  • Tamm LK Department of Biophysical Chemistry, University of Basel, Switzerland.
  • Bartoldus I
  • 1990-10-15
Published in:
  • FEBS letters. - 1990
Amino Acid Sequence
Animals
Cardiolipins
Cattle
Circular Dichroism
Electron Transport Complex IV
Lipid Bilayers
Membrane Lipids
Mitochondria, Heart
Molecular Sequence Data
Phosphatidylcholines
Phosphatidylglycerols
Protein Conformation
Protein Sorting Signals
English The secondary structure of the synthetic signal peptide of cytochrome c oxidase subunit IV (coxIV-25) has been measured by circular dichroism spectroscopy in different lipid environments. CoxIV-25 is polymorphic in membranes. It forms an amphiphilic alpha-helix both in negatively charged lipid bilayers (up to 49% helix) and in detergent micelles (up to 42% helix). In association with bilayers of the zwitterionic lipid phosphatidylcholine, coxIV-25 takes an aperiodic, unidentified structure. CoxIV-25 is also partially alpha-helical in bilayers of cardiolipin, mitochondrial lipid extracts and mixtures of synthetic phosphatidylcholine and phosphatidylglycerol.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/272040
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