Sleep-Wake Neurochemistry.
- Holst SC Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, 28 Juliane Maries Vej 6931, Copenhagen 2100, Denmark. Electronic address: holst@nru.dk.
- Landolt HP Institute of Pharmacology and Toxicology, University of Zürich, Winterthurerstrasse 190, Zürich 8057, Switzerland; Zürich Center for Interdisciplinary Sleep Research (ZiS), University of Zürich, Zürich, Switzerland.
- 2018-05-16
Published in:
- Sleep medicine clinics. - 2018
Acetylcholine
Adenosine
Dopamine
GABA
Glutamate
Neuromodulators
Neurotransmitters
Norepinephrine
Animals
Brain Chemistry
Humans
Neurotransmitter Agents
Sleep
Sleep Wake Disorders
Wakefulness
English
The regulated alternations between wakefulness and sleep states reflect complex behavioral processes, orchestrated by distinct neurochemical changes in brain parenchyma. No single neurotransmitter or neuromodulator controls the sleep-wake states in isolation. Rather, fine-tuned interactions within organized neuronal circuits regulate waking and sleep states and drive their transitions. Structural or functional dysregulation and medications interfering with these ensembles can lead to sleep-wake disorders and exert wanted or unwanted pharmacological actions on sleep-wake states. Knowledge of the neurochemical bases of sleep-wake states, which will be discussed in this article, provides the conceptual framework for understanding pharmacological effects on sleep and wake.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1016/j.jsmc.2018.03.002
- PMID 29759265
- Persistent URL
- https://folia.unifr.ch/global/documents/271337
Statistics
Document views: 31
File downloads:
- fulltext.pdf: 0