Chromosomal instability drives metastasis through a cytosolic DNA response.

• Bakhoum SF Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
• Ngo B Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10065, USA.
• Laughney AM Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
• Cavallo JA Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
• Murphy CJ Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10065, USA.
• Ly P Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California 92093, USA.
• Shah P Nancy E. and Peter C. Meinig School of Biomedical Engineering & Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14850, USA.
• Sriram RK Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10065, USA.
• Watkins TBK The Francis Crick Institute, London NW1 1AT, UK.
• Taunk NK Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
• Duran M Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
• Pauli C Institute for Pathology and Molecular Pathology, University Hospital Zurich, Zurich 8091, Switzerland.
• Shaw C Molecular Cytogenetics Core, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
• Chadalavada K Molecular Cytogenetics Core, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
• Rajasekhar VK Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
• Genovese G The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
• Venkatesan S UCL Cancer Institute, London WC1E 6BT, UK.
• Birkbak NJ The Francis Crick Institute, London NW1 1AT, UK.
• McGranahan N The Francis Crick Institute, London NW1 1AT, UK.
• Lundquist M Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10065, USA.
• LaPlant Q Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
• Healey JH Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
• Elemento O Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10065, USA.
• Chung CH Moffitt Cancer Center, Tampa, Florida 33612, USA.
• Lee NY Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
• Imielenski M Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10065, USA.
• Nanjangud G Molecular Cytogenetics Core, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
• Pe'er D Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
• Cleveland DW Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California 92093, USA.
• Powell SN Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
• Lammerding J Nancy E. and Peter C. Meinig School of Biomedical Engineering & Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14850, USA.
• Swanton C The Francis Crick Institute, London NW1 1AT, UK.
• Cantley LC Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10065, USA.

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Animals

Brain Neoplasms

Breast Neoplasms

Carcinoma, Squamous Cell

Cell Line

Chromosomal Instability

Chromosome Segregation

Cytosol

DNA, Neoplasm

Female

Head and Neck Neoplasms

Humans

Inflammation

Membrane Proteins

Mesoderm

Mice

Micronuclei, Chromosome-Defective

NF-kappa B

Neoplasm Metastasis

Nucleotidyltransferases

Xenograft Model Antitumor Assays