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Tailoring lumazine synthase assemblies for bionanotechnology.
Journal article

Tailoring lumazine synthase assemblies for bionanotechnology.

  • 2018-05-02
Published in:
  • Chemical Society reviews. - 2018
Models, Molecular
Molecular Conformation
Multienzyme Complexes
Nanotechnology
Particle Size
Protein Engineering
English Nanoscale compartments formed by hierarchical protein self-assembly are valuable platforms for nanotechnology development. The well-defined structure and broad chemical functionality of protein cages, as well as their amenability to genetic and chemical modification, have enabled their repurposing for diverse applications. In this review, we summarize progress in the engineering of the cage-forming enzyme lumazine synthase. This bacterial nanocompartment has proven to be a malleable scaffold. The natural protein has been diversified to afford a family of unique proteinaceous capsules that have been modified, evolved and assembled with other components to produce nanoreactors, artificial organelles, delivery vehicles and virus mimics.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/266177
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