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Impact of human milk bacteria and oligosaccharides on neonatal gut microbiota establishment and gut health.
Journal article

Impact of human milk bacteria and oligosaccharides on neonatal gut microbiota establishment and gut health.

  • Jost T T. Jost, C. Lacroix, and C. Chassard are with the Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, Zurich, Switzerland. C. Braegger is with the Division of Gastroenterology and Nutrition, University Children's Hospital Zurich, Zurich, Switzerland.
  • Lacroix C T. Jost, C. Lacroix, and C. Chassard are with the Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, Zurich, Switzerland. C. Braegger is with the Division of Gastroenterology and Nutrition, University Children's Hospital Zurich, Zurich, Switzerland. christophe.lacroix@hest.ethz.ch.
  • Braegger C T. Jost, C. Lacroix, and C. Chassard are with the Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, Zurich, Switzerland. C. Braegger is with the Division of Gastroenterology and Nutrition, University Children's Hospital Zurich, Zurich, Switzerland.
  • Chassard C T. Jost, C. Lacroix, and C. Chassard are with the Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, Zurich, Switzerland. C. Braegger is with the Division of Gastroenterology and Nutrition, University Children's Hospital Zurich, Zurich, Switzerland.
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  • 2015-06-18
Published in:
  • Nutrition reviews. - 2015
enteromammary pathway
gut health
human milk bacteria
human milk oligosaccharides
microbiota
neonate
Bacteria
Bacteroides
Bifidobacterium
Gastrointestinal Microbiome
Gastrointestinal Tract
Humans
Infant
Lactobacillus
Milk, Human
Oligosaccharides
English Neonatal gut microbiota establishment represents a crucial stage for gut maturation, metabolic and immunologic programming, and consequently short- and long-term health status. Human milk beneficially influences this process due to its dynamic profile of age-adapted nutrients and bioactive components and by providing commensal maternal bacteria to the neonatal gut. These include Lactobacillus spp., as well as obligate anaerobes such as Bifidobacterium spp., which may originate from the maternal gut via an enteromammary pathway as a novel form of mother-neonate communication. Additionally, human milk harbors a broad range of oligosaccharides that promote the growth and activity of specific bacterial populations, in particular, Bifidobacterium and Bacteroides spp. This review focuses on the diversity and origin of human milk bacteria, as well as on milk oligosaccharides that influence neonatal gut microbiota establishment. This knowledge can be used to develop infant formulae that more closely mimic nature's model and sustain a healthy gut microbiota.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/265842
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