Journal article
Hepatocellular Adenomas: Morphology and Genomics.
- Bioulac-Sage P Inserm U 1053, Université Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France. Electronic address: paulette.bioulac-sage@u-bordeaux2.fr.
- Sempoux C Service of Clinical Pathology, Lausanne University Hospital, Institute of Pathology, Rue du Bugnon 25, CH-1011 Lausanne, Switzerland.
- Balabaud C Inserm U 1053, Université Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France.
- 2017-05-17
Published in:
- Gastroenterology clinics of North America. - 2017
Genomics
Genoptye/phenotype
Hepatocellular adenoma classification
Hepatocellular adenomas
Malignant transformation
Adenoma, Liver Cell
Biomarkers
Fatty Liver
Genotype
Hepatocyte Nuclear Factor 1-alpha
Humans
Liver Neoplasms
Phenotype
beta Catenin
English
Hepatocellular adenomas (HCAs) are rare benign tumors. This single entity has been split into 3 subtypes corresponding to specific mutations: HNF1α-inactivated HCA; inflammatory HCA related to different mutations, all leading to activation of STAT3 pathway; and β-catenin-activated HCA related to CTNNB1 mutations. The risk of malignant transformation depends on the level of β-catenin activation, reported mainly for exon 3, including S45. It is possible using specific immunohistochemical markers to identify the 3 different HCA subtypes and the level of β-catenin activation. Fewer than 10% of HCAs remain unclassified.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.gtc.2017.01.003
- PMID 28506364
- Persistent URL
- https://folia.unifr.ch/global/documents/265553
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