High-fluoride toothpaste: a multicenter randomized controlled trial in adults.
- Srinivasan M Division of Gerodontology and Removable Prosthodontics, School of Dental Medicine, University of Geneva, Geneva, Switzerland.
- Schimmel M
- Riesen M
- Ilgner A
- Wicht MJ
- Warncke M
- Ellwood RP
- Nitschke I
- Müller F
- Noack MJ
- 2013-12-21
Published in:
- Community dentistry and oral epidemiology. - 2014
Duraphat 5000 ppm F
adult
dental caries
high-fluoride toothpaste
oral health
prevention
randomized controlled trial
root caries
sodium fluoride
Adolescent
Adult
Aged
Cariostatic Agents
Dental Caries
Female
Fluorides, Topical
Germany
Hardness
Humans
Male
Middle Aged
Single-Blind Method
Sodium Fluoride
Surface Properties
Toothpastes
English
OBJECTIVE
The aim of this single - blind, multicenter, parallel, randomized controlled trial was to evaluate the effectiveness of the application of a high-fluoride toothpaste on root caries in adults.
METHODS
Adult patients (n = 130, ♂ = 74, ♀ = 56; mean age ± SD: 56.9 ± 12.9) from three participating centers, diagnosed with root caries, were randomly allocated into two groups: Test (n = 64, ♂ = 37, ♀ = 27; lesions = 144; mean age: 59.0 ± 12.1; intervention: high-fluoride toothpaste with 5000 ppm F), and Control (n = 66, ♂ = 37, ♀ = 29; lesions = 160; mean age: 54.8 ± 13.5; intervention: regular-fluoride toothpaste with 1350 ppm F) groups. Clinical examinations and surface hardness scoring of the carious lesions were performed for each subject at specified time intervals (T0 - at baseline before intervention, T1 - at 3 months and T2 - at 6 months after intervention). Mean surface hardness scores (HS) were calculated for each patient. Statistical analyses comprised of two-way analysis of variance and post hoc comparisons using the Bonferroni-Dunn correction.
RESULTS
At T0 , there was no statistical difference between the two groups with regard to gender (P = 0.0682, unpaired t-test), or age (P = 0.9786, chi-squared test), and for the overall HS (Test group: HS = 3.4 ± 0.61;
CONTROL GROUP
HS = 3.4 ± 0.66; P = 0.8757, unpaired t-test). The anova revealed significantly better HS for the test group than for the control groups (T1 : Test group: HS = 2.9 ± 0.67;
CONTROL GROUP
HS = 3.1 ± 0.75; T2 : Test group: HS = 2.4 ± 0.81;
CONTROL GROUP
HS = 2.8 ± 0.79; P < 0.0001). However, the interaction term time-point*group was not significant.
CONCLUSIONS
The application of a high-fluoride containing dentifrice (5000 ppm F) in adults, twice daily, significantly improves the surface hardness of otherwise untreated root caries lesions when compared with the use of regular fluoride containing (1350 ppm F) toothpastes.
The aim of this single - blind, multicenter, parallel, randomized controlled trial was to evaluate the effectiveness of the application of a high-fluoride toothpaste on root caries in adults.
METHODS
Adult patients (n = 130, ♂ = 74, ♀ = 56; mean age ± SD: 56.9 ± 12.9) from three participating centers, diagnosed with root caries, were randomly allocated into two groups: Test (n = 64, ♂ = 37, ♀ = 27; lesions = 144; mean age: 59.0 ± 12.1; intervention: high-fluoride toothpaste with 5000 ppm F), and Control (n = 66, ♂ = 37, ♀ = 29; lesions = 160; mean age: 54.8 ± 13.5; intervention: regular-fluoride toothpaste with 1350 ppm F) groups. Clinical examinations and surface hardness scoring of the carious lesions were performed for each subject at specified time intervals (T0 - at baseline before intervention, T1 - at 3 months and T2 - at 6 months after intervention). Mean surface hardness scores (HS) were calculated for each patient. Statistical analyses comprised of two-way analysis of variance and post hoc comparisons using the Bonferroni-Dunn correction.
RESULTS
At T0 , there was no statistical difference between the two groups with regard to gender (P = 0.0682, unpaired t-test), or age (P = 0.9786, chi-squared test), and for the overall HS (Test group: HS = 3.4 ± 0.61;
CONTROL GROUP
HS = 3.4 ± 0.66; P = 0.8757, unpaired t-test). The anova revealed significantly better HS for the test group than for the control groups (T1 : Test group: HS = 2.9 ± 0.67;
CONTROL GROUP
HS = 3.1 ± 0.75; T2 : Test group: HS = 2.4 ± 0.81;
CONTROL GROUP
HS = 2.8 ± 0.79; P < 0.0001). However, the interaction term time-point*group was not significant.
CONCLUSIONS
The application of a high-fluoride containing dentifrice (5000 ppm F) in adults, twice daily, significantly improves the surface hardness of otherwise untreated root caries lesions when compared with the use of regular fluoride containing (1350 ppm F) toothpastes.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1111/cdoe.12090
- PMID 24354454
- Persistent URL
- https://folia.unifr.ch/global/documents/261476
Statistics
Document views: 22
File downloads:
- fulltext.pdf: 0