Journal article
Human Cochlear Nucleus on 7 Tesla Diffusion Tensor Imaging: Insights Into Micro-anatomy and Function for Auditory Brainstem Implant Surgery.
- Epprecht L Eaton-Peabody Laboratories, Massachusetts Eye and Ear.
- Qureshi A Eaton-Peabody Laboratories, Massachusetts Eye and Ear.
- Kozin ED Eaton-Peabody Laboratories, Massachusetts Eye and Ear.
- Vachicouras N Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft, Bioelectronic Interfaces, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
- Huber AM Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Zurich, Zurich, Switzerland.
- Kikinis R Surgical Planning Laboratory, Harvard Medical School, Boston, Massachusetts, USA.
- Makris N Surgical Planning Laboratory, Harvard Medical School, Boston, Massachusetts, USA.
- Brown MC Eaton-Peabody Laboratories, Massachusetts Eye and Ear.
- Reinshagen KL Department of Radiology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts, USA.
- Lee DJ Eaton-Peabody Laboratories, Massachusetts Eye and Ear.
- 2020-03-17
Published in:
- Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. - 2020
English
OBJECTIVE
The cochlear nucleus (CN) is the target of the auditory brainstem implant (ABI). Most ABI candidates have Neurofibromatosis Type 2 (NF2) and distorted brainstem anatomy from bilateral vestibular schwannomas. The CN is difficult to characterize as routine structural MRI does not resolve detailed anatomy. We hypothesize that diffusion tensor imaging (DTI) enables both in vivo localization and quantitative measurements of CN morphology.
STUDY DESIGN
We analyzed 7 Tesla (T) DTI images of 100 subjects (200 CN) and relevant anatomic structures using an MRI brainstem atlas with submillimetric (50 μm) resolution.
SETTING
Tertiary referral center.
PATIENTS
Young healthy normal hearing adults.
INTERVENTION
Diagnostic.
MAIN OUTCOME MEASURES
Diffusion scalar measures such as fractional anisotropy (FA), mean diffusivity (MD), mode of anisotropy (Mode), principal eigenvectors of the CN, and the adjacent inferior cerebellar peduncle (ICP).
RESULTS
The CN had a lamellar structure and ventral-dorsal fiber orientation and could be localized lateral to the inferior cerebellar peduncle (ICP). This fiber orientation was orthogonal to tracts of the adjacent ICP where the fibers run mainly caudal-rostrally. The CN had lower FA compared to the medial aspect of the ICP (0.44 ± 0.09 vs. 0.64 ± 0.08, p < 0.001).
CONCLUSIONS
7T DTI enables characterization of human CN morphology and neuronal substructure. An ABI array insertion vector directed more caudally would better correspond to the main fiber axis of CN. State-of-the-art DTI has implications for ABI preoperative planning and future image guidance-assisted placement of the electrode array.
The cochlear nucleus (CN) is the target of the auditory brainstem implant (ABI). Most ABI candidates have Neurofibromatosis Type 2 (NF2) and distorted brainstem anatomy from bilateral vestibular schwannomas. The CN is difficult to characterize as routine structural MRI does not resolve detailed anatomy. We hypothesize that diffusion tensor imaging (DTI) enables both in vivo localization and quantitative measurements of CN morphology.
STUDY DESIGN
We analyzed 7 Tesla (T) DTI images of 100 subjects (200 CN) and relevant anatomic structures using an MRI brainstem atlas with submillimetric (50 μm) resolution.
SETTING
Tertiary referral center.
PATIENTS
Young healthy normal hearing adults.
INTERVENTION
Diagnostic.
MAIN OUTCOME MEASURES
Diffusion scalar measures such as fractional anisotropy (FA), mean diffusivity (MD), mode of anisotropy (Mode), principal eigenvectors of the CN, and the adjacent inferior cerebellar peduncle (ICP).
RESULTS
The CN had a lamellar structure and ventral-dorsal fiber orientation and could be localized lateral to the inferior cerebellar peduncle (ICP). This fiber orientation was orthogonal to tracts of the adjacent ICP where the fibers run mainly caudal-rostrally. The CN had lower FA compared to the medial aspect of the ICP (0.44 ± 0.09 vs. 0.64 ± 0.08, p < 0.001).
CONCLUSIONS
7T DTI enables characterization of human CN morphology and neuronal substructure. An ABI array insertion vector directed more caudally would better correspond to the main fiber axis of CN. State-of-the-art DTI has implications for ABI preoperative planning and future image guidance-assisted placement of the electrode array.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1097/MAO.0000000000002565
- PMID 32176138
- Persistent URL
- https://folia.unifr.ch/global/documents/261034
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