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[Progressive multifocal leukoencephalopathy].
Journal article

[Progressive multifocal leukoencephalopathy].

  • Warnke C Klinik für Neurologie, Medizinische Fakultät, Universitätsklinikum Düsseldorf, Heinrich-Heine-Universität Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Deutschland. warnke@uni-duesseldorf.de.
  • Wattjes MP Abteilung für Radiologie und Nuklearmedizin, VU University Medical Center, Amsterdam, Niederlande.
  • Adams O Institut für Virologie, Medizinische Fakultät, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland.
  • Hartung HP Klinik für Neurologie, Medizinische Fakultät, Universitätsklinikum Düsseldorf, Heinrich-Heine-Universität Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Deutschland.
  • Martin R Klinik für Neurologie, Universitätsspital Zürich, Zürich, Schweiz.
  • Weber T Klinik für Neurologie, Kath. Marienkrankenhaus, Hamburg, Deutschland.
  • Stangel M Klinik für Neurologie, Medizinische Hochschule Hannover, Hannover, Deutschland.
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  • 2016-10-13
Published in:
  • Der Nervenarzt. - 2016
Cerebrospinal fluid
JC polyomavirus
Multiple sclerosis
Natalizumab
PML
Biomarkers
Case Management
Diagnostic Techniques, Neurological
Evidence-Based Medicine
Humans
Leukoencephalopathy, Progressive Multifocal
Treatment Outcome
English Progressive multifocal leukoencephalopathy (PML) is a disease of immunosuppressed patients caused by the JC polyomavirus (JCPyV). Due to the elevated risk in patients treated with natalizumab for multiple sclerosis (MS) and also treatment with other biologicals for different indications, the relevance of PML has increased in recent years. This article summarizes the published knowledge on the biology and pathogenesis of PML with a focus on the role of cerebrospinal fluid diagnostics in the work-up for PML and the current PML case definition. Current recommendations regarding risk management are discussed, as are possible therapies and prevention.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/260381
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