Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS).

• Herrick AL Centre for Musculoskeletal Research, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
• Pan X Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
• Peytrignet S Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
• Lunt M Centre for Musculoskeletal Research, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
• Hesselstrand R Department of Rheumatology, Lund University, Lund, Sweden.
• Mouthon L Service de Médecine Interne, Hôpital Cochin, Centre de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Université Paris Descartes, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
• Silman A Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences,University of Oxford, Oxford, UK.
• Brown E Member of Steering Committee, contact via Professor Herrick, The University of Manchester, Manchester, UK.
• Czirják L Department of Rheumatology and Immunology, Medical Center, University of Pécs, Pecs, Hungary.
• Distler JHW Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany.
• Distler O Department of Rheumatology, University of Zurich, Zurich, Switzerland.
• Fligelstone K Royal Free London NHS Foundation Trust, London, UK.
• Gregory WJ Rehabilitation Services, Salford Royal NHS Foundation Trust, Salford, UK.
• Ochiel R Royal Free London NHS Foundation Trust, London, UK.
• Vonk M Department of the Rheumatic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
• Ancuţa C Rheumatology 2 Department, "Grigore T. Popa" University of Medicine and Pharmacy, Clinical Rehabilitation Hospital, Iași, Romania.
• Ong VH UCL Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK.
• Farge D Unité Clinique de Médecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Hôpital Saint-Louis, AP-HP Assistance Publique des Hôpitaux de Paris, INSERM UMRS 1160, Paris Denis Diderot University, France.
• Hudson M Jewish General Hospital, Lady Davis Institute and McGill University, Montreal, Canada.
• Matucci-Cerinic M Department Experimental and Clinical Medicine, Division of Rheumatology AOUC, University of Florence, Florence, Italy.
• Balbir-Gurman A Shine Rheumatology Unit, Rambam Heath Care Campus; Rappaport Faculty of Medicine, Haifa, Israel.
• Midtvedt Ø Rheumatology Unit, Oslo University Hospital Rikshospitalet, Oslo, Norway.
• Jordan AC Queen Elizabeth Hospital Birmingham, UHB Foundation Trust, Birmingham, UK.
• Jobanputra P Queen Elizabeth Hospital Birmingham, UHB Foundation Trust, Birmingham, UK.
• Stevens W St Vincent's Hospital, Melbourne, Australia.
• Moinzadeh P Department for Dermatology, University of Cologne Kerpenerstr. 62, Köln, Germany.
• Hall FC Cambridge University NHS Hospital Foundation Trust, Cambridge, UK.
• Agard C Department of Internal Medicine, Hôtel-Dieu Hospital, University of Nantes, Nantes, France.
• Anderson ME University of Liverpool, Aintree University Hospital, Liverpool, UK.
• Diot E Service de Médecine Interne, Hôpital Bretonneau Tours Cedex, France.
• Madhok R Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, UK.
• Akil M Sheffield Teaching Hospitals, Sheffield, UK.
• Buch MH Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, UK.
• Chung L Stanford University, Stanford, California, USA.
• Damjanov N University of Belgrade School of Medicine, Institute of Rheumatology, Belgrade, Serbia.
• Gunawardena H Clinical and Academic Rheumatology, North Bristol NHS Trust, Bristol, UK.
• Lanyon P Nottingham University Hospitals NHS Trust, and Nottingham NHS Treatment Centre, Nottingham, UK.
• Ahmad Y Peter Maddison Rheumatology Centre, Llandudno, UK.
• Chakravarty K Queens Hospital, Romford, UK.
• Jacobsen S University of Copenhagen, Copenhagen Lupus and Vasculitis Clinic, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark.
• MacGregor AJ Norwich Medical School, University of East Anglia, Norwich, UK.
• McHugh N Royal National Hospital for Rheumatic Diseases, Bath, UK.
• Müller-Ladner U Department of Rheumatology and Clinical Immunology, Justus-Liebig University Giessen, Bad Nauheim, Germany.
• Riemekasten G Department of Rheumatology, University of Lübeck, Lübeck, Germany.
• Becker M Department of Rheumatology and Clinical Immunology, University Hospital Charité Berlin, Berlin, Germany.
• Roddy J Department of Rheumatology, Royal Perth Hospital, Perth, Australia.
• Carreira PE Servicio de Reumatologia. Hospital Universitario 12 de Octubre, Madrid, Spain.
• Fauchais AL Internal Medicine Unit, Limoges University Hospital, France.
• Hachulla E Département de Médecine Interne et Immunologie Clinique, Centre National de Référence Maladies Systémiques etAuto-immunes Rares, Université de Lille, Inserm, U995, FHU Immune-Mediated Inflammatory Diseases and Targeted Therapies, Lille, France.
• Hamilton J Gateshead Hospitals Foundation Trust, Gateshead, UK.
• İnanç M Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul, Turkey.
• McLaren JS Fife Rheumatic Diseases Unit, Whyteman's Brae Hospital, Kirkcaldy, UK.
• van Laar JM Department of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, The Netherlands.
• Pathare S James Cook University Hospital, Middlesbrough, UK.
• Proudman S Rheumatology Unit, Royal Adelaide Hospital, and Discipline of Medicine, University of Adelaide, Adelaide, South Australia.
• Rudin A Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden.
• Sahhar J Monash Centre for Inflammatory Diseases, Monash University, Clayton, Melbourne, Australia.
• Coppere B Department of Internal Medicine, Hôpital Edouard Herriot, Lyon, France.
• Serratrice C Department of Internal Medicine, Foundation Hospital Saint Joseph, Marseille, France.
• Sheeran T Cannock Chase Hospital, Cannock, UK.
• Veale DJ St Vincent's University Hospital, Dublin, Ireland.
• Grange C Department of Internal Medicine, Centre Hospitalier Lyon Sud, Pierre Benite, France.
• Trad GS Internal Medecine, Ambroise Paré Hospital, Boulogne Billancourt, France.
• Denton CP UCL Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK.

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Cyclophosphamide

Methotrexate

Systemic Sclerosis

Treatment

Adult

Antibodies, Antinuclear

Autoantibodies

Cohort Studies

Cyclophosphamide

Early Medical Intervention

Europe

Female

Humans

Immunosuppressive Agents

Male

Methotrexate

Middle Aged

Mycophenolic Acid

Nuclear Proteins

Prospective Studies

RNA Polymerase III

Scleroderma, Diffuse

Severity of Illness Index

Survival Rate

Treatment Outcome