Network connectivity determines cortical thinning in early Parkinson's disease progression.
- Yau Y Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
- Zeighami Y Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
- Baker TE Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
- Larcher K Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
- Vainik U Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
- Dadar M Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
- Fonov VS Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
- Hagmann P Department of Radiology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 21, 1011, Lausanne, Switzerland.
- Griffa A Brain Center Rudolf Magnus, UMC Utrecht, Heidelberglaan 100, A01.126, 3508 GA, Utrecht, The Netherlands.
- Mišić B Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
- Collins DL Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.
- Dagher A Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada. alain.dagher@mcgill.ca.
- 2018-01-04
Published in:
- Nature communications. - 2018
Aged
Case-Control Studies
Cerebral Cortex
Cognition
Connectome
Disease Progression
Female
Humans
Longitudinal Studies
Male
Middle Aged
Parkinson Disease
English
Here we test the hypothesis that the neurodegenerative process in Parkinson's disease (PD) moves stereotypically along neural networks, possibly reflecting the spread of toxic alpha-synuclein molecules. PD patients (n = 105) and matched controls (n = 57) underwent T1-MRI at entry and 1 year later as part of the Parkinson's Progression Markers Initiative. Over this period, PD patients demonstrate significantly greater cortical thinning than controls in parts of the left occipital and bilateral frontal lobes and right somatomotor-sensory cortex. Cortical thinning is correlated to connectivity (measured functionally or structurally) to a "disease reservoir" evaluated by MRI at baseline. The atrophy pattern in the ventral frontal lobes resembles one described in certain cases of Alzheimer's disease. Our findings suggest that disease propagation to the cortex in PD follows neuronal connectivity and that disease spread to the cortex may herald the onset of cognitive impairment.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1038/s41467-017-02416-0
- PMID 29295991
- Persistent URL
- https://folia.unifr.ch/global/documents/259378
Statistics
Document views: 14
File downloads:
- fulltext.pdf: 0