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The spared nerve injury model of neuropathic pain.
Journal article

The spared nerve injury model of neuropathic pain.

  • Pertin M Pain Research Unit, Department of Anesthesiology, University Hospital Center, University of Lausanne, Lausanne, Switzerland.
  • Gosselin RD
  • Decosterd I
  • 2012-02-22
Published in:
  • Methods in molecular biology (Clifton, N.J.). - 2012
Animals
Disease Models, Animal
Mice
Neuralgia
Pain Threshold
Peripheral Nerve Injuries
Rats
Rats, Sprague-Dawley
English The spared nerve injury (SNI) model mimics human neuropathic pain related to peripheral nerve injury and is based upon an invasive but simple surgical procedure. Since its first description in 2000, it has displayed a remarkable development. It produces a robust, reliable and long-lasting neuropathic pain-like behaviour (allodynia and hyperalgesia) as well as the possibility of studying both injured and non-injured neuronal populations in the same spinal ganglion. Besides, variants of the SNI model have been developed in rats, mice and neonatal/young rodents, resulting in several possible angles of analysis. Therefore, the purpose of this chapter is to provide a detailed guidance regarding the SNI model and its variants, highlighting its surgical and behavioural testing specificities.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/259167
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