Journal article
European Veterinary Renal Pathology Service: A Survey Over a 7-Year Period (2008-2015).
- Aresu L Department of Comparative Biomedicine and Food Science, University of Padova, Agripolis Legnaro, PD, Italy.
- Martini V Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Milano, Italy.
- Benali SL La Vallonea Laboratory, Alessano, Le, Italy.
- Brovida C Ospedale Veterinario ANUBI Strada Genova, Moncalieri, Italy.
- Cianciolo RE Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH.
- Dalla Riva R Department of Comparative Biomedicine and Food Science, University of Padova, Agripolis Legnaro, PD, Italy.
- Trez D Department of Comparative Biomedicine and Food Science, University of Padova, Agripolis Legnaro, PD, Italy.
- Van Der Lugt JJ IDEXX Europe, BV, Hoofddorp, The Netherlands.
- Van Dongen A Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
- Zini E Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
- 2017-08-02
Published in:
- Journal of veterinary internal medicine. - 2017
Diagnosis
Dog
Electron microscopy
Glomerulonephritis
Renal biopsy
Animals
Biopsy
Dog Diseases
Dogs
Europe
Female
Glomerulonephritis
Kidney
Kidney Diseases
Male
Microscopy
Microscopy, Electron
Registries
Surveys and Questionnaires
English
BACKGROUND
The European Veterinary Renal Pathology Service (EVRPS) is the first Web-based registry for canine renal biopsy specimens in Europe.
HYPOTHESIS/OBJECTIVES
The aim was to verify whether differences exist between the clinical and laboratory presentation of dogs with nephropathy according to renal pathological findings, as defined by light and electron microscopy of renal biopsy specimens submitted to EVRPS.
ANIMALS
Renal biopsy specimens of dogs were collected from the archive of the service (n = 254). Cases were included if both light and electron microscopy were available (n = 162).
METHODS
Renal biopsy specimens were classified based on the morphological diagnoses. Thereafter, they were grouped into 3 disease categories, including immune-complex-mediated glomerulonephritis (ICGN), non-immune-complex-mediated GN (non-ICGN), and renal lesions not otherwise specified (RL-NOS). Differences among morphological diagnoses and among disease categories were investigated for clinical and laboratory variables.
RESULTS
Serum albumin concentration was lower in dogs with ICGN than in those with non-ICGN (P = 0.006) or RL-NOS (P = 0.000), and the urine protein-to-creatinine ratio (UPC) was significantly higher in ICGN than in the other 2 disease categories. Regarding morphological diagnoses, albumin was significantly lower in amyloidosis (AMY) and membranous (MGN), membranoproliferative (MPGN) or mixed glomerulonephritis (MixGN) than in minimal change disease, primary (FSGS I) or secondary (FSGS II) focal and segmental glomerulosclerosis and juvenile nephropathies (JN). The UPC was higher in MPGN than in FSGS I and FSGS II.
CONCLUSIONS AND CLINICAL IMPORTANCE
Dogs with ICGN, in particular MPGN, had higher protein loss than those with non-ICGN or RL-NOS, leading to more severe hypoalbuminemia. Clinical and laboratory differentiation among dogs with the different morphological diagnoses and among dogs with different disease categories was difficult due to overlapping results.
The European Veterinary Renal Pathology Service (EVRPS) is the first Web-based registry for canine renal biopsy specimens in Europe.
HYPOTHESIS/OBJECTIVES
The aim was to verify whether differences exist between the clinical and laboratory presentation of dogs with nephropathy according to renal pathological findings, as defined by light and electron microscopy of renal biopsy specimens submitted to EVRPS.
ANIMALS
Renal biopsy specimens of dogs were collected from the archive of the service (n = 254). Cases were included if both light and electron microscopy were available (n = 162).
METHODS
Renal biopsy specimens were classified based on the morphological diagnoses. Thereafter, they were grouped into 3 disease categories, including immune-complex-mediated glomerulonephritis (ICGN), non-immune-complex-mediated GN (non-ICGN), and renal lesions not otherwise specified (RL-NOS). Differences among morphological diagnoses and among disease categories were investigated for clinical and laboratory variables.
RESULTS
Serum albumin concentration was lower in dogs with ICGN than in those with non-ICGN (P = 0.006) or RL-NOS (P = 0.000), and the urine protein-to-creatinine ratio (UPC) was significantly higher in ICGN than in the other 2 disease categories. Regarding morphological diagnoses, albumin was significantly lower in amyloidosis (AMY) and membranous (MGN), membranoproliferative (MPGN) or mixed glomerulonephritis (MixGN) than in minimal change disease, primary (FSGS I) or secondary (FSGS II) focal and segmental glomerulosclerosis and juvenile nephropathies (JN). The UPC was higher in MPGN than in FSGS I and FSGS II.
CONCLUSIONS AND CLINICAL IMPORTANCE
Dogs with ICGN, in particular MPGN, had higher protein loss than those with non-ICGN or RL-NOS, leading to more severe hypoalbuminemia. Clinical and laboratory differentiation among dogs with the different morphological diagnoses and among dogs with different disease categories was difficult due to overlapping results.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1111/jvim.14796
- PMID 28763127
- Persistent URL
- https://folia.unifr.ch/global/documents/256087
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