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Sodium iron EDTA [NaFe(III)EDTA] as a food fortificant does not influence absorption and urinary excretion of manganese in healthy adults.

  • Davidsson L Laboratory for Human Nutrition, Swiss Federal Institute of Technology, ETH Zürich, CH-8803 Rüschlikon, Switzerland.
  • Almgren A
  • Hurrell RF
  • 1998-07-03
Published in:
  • The Journal of nutrition. - 1998
Absorption
Adult
Cross-Over Studies
Edetic Acid
Edible Grain
Female
Ferric Compounds
Ferrous Compounds
Food, Fortified
Humans
Infant Food
Iron
Iron Chelating Agents
Male
Manganese
Middle Aged
Nutritional Status
Phytic Acid
Radioisotopes
Weaning
English NaFe(III)EDTA is a promising iron (Fe) compound for food fortification programs because of its high Fe bioavailability from meals containing dietary inhibitors of Fe absorption such as phytic acid. However, this Fe compound is not currently used in any large-scale fortification program because of concern over its possible negative influence on the metabolism of other essential minerals or its possible influence on the absorption of potentially toxic elements, such as manganese (Mn). In this study, Mn absorption and urinary excretion were studied in adults after intake of an Fe-fortified weaning cereal labeled with 54Mn. In a crossover design, the fortification of the weaning cereal with Fe as NaFeEDTA was compared with ferrous sulfate. Manganese absorption was measured by extrapolation from whole-body retention data 10-30 d after intake, and urinary excretion of 54Mn was measured over 7 d. No significant differences in 54Mn absorption or urinary excretion were found; 1.1 +/- 0.15 and 0.91 +/- 0.35% of the ingested dose was absorbed from the cereal fortified with NaFe(III)EDTA and FeSO4, respectively. Urinary excretion of 54Mn was very low; the total radioactivity in urine represented 1.1 +/- 0.55% of the absorbed dose with NaFe(III)EDTA and 0.72 +/- 0.53% of the absorbed dose with FeSO4. Until now, Fe-fortification programs have met with only limited success. The introduction of NaFeEDTA as a food fortificant could be a useful tool to provide bioavailable Fe to vulnerable groups in the population and thus aid in combating Fe deficiency.
Language
  • English
Open access status
bronze
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Persistent URL
https://folia.unifr.ch/global/documents/254484
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