Alterations in the local myocardial motion pattern in patients suffering from pressure overload due to aortic stenosis.
- Stuber M Institute of Biomedical Engineering, University and ETH Zurich Department of Internal Medicine, Zurich, Switzerland.
- Scheidegger MB
- Fischer SE
- Nagel E
- Steinemann F
- Hess OM
- Boesiger P
- 1999-07-27
Published in:
- Circulation. - 1999
Adult
Aged
Aortic Valve Stenosis
Diastole
Humans
Hypertension
Magnetic Resonance Imaging
Middle Aged
Motion
Myocardial Contraction
Myocardium
Reference Values
Rotation
Sports
Systole
Torsion Abnormality
Ventricular Function, Left
English
BACKGROUND
MR tissue tagging allows the noninvasive assessment of the locally and temporally resolved motion pattern of the left ventricle. Alterations in cardiac torsion and diastolic relaxation of the left ventricle were studied in patients with aortic stenosis and were compared with those of healthy control subjects and championship rowers with physiological volume-overload hypertrophy.
METHODS AND RESULTS
Twelve aortic stenosis patients, 11 healthy control subjects with normal left ventricular function, and 11 world-championship rowers were investigated for systolic and diastolic heart wall motion on a basal and an apical level of the myocardium. Systolic torsion and untwisting during diastole were examined by use of a novel tagging technique (CSPAMM) that provides access to systolic and diastolic motion data. In the healthy heart, the left ventricle performs a systolic wringing motion, with a counterclockwise rotation at the apex and a clockwise rotation at the base. Apical untwisting precedes diastolic filling. In the athlete's heart, torsion and untwisting remain unchanged compared with those of the control subjects. In aortic stenosis patients, torsion is significantly increased and diastolic apical untwisting is prolonged compared with those of control subjects or athletes.
CONCLUSIONS
Torsional behavior as observed in pressure- and volume-overloaded hearts is consistent with current theoretical findings. A delayed diastolic untwisting in the pressure-overloaded hearts of the patients may contribute to a tendency toward diastolic dysfunction.
MR tissue tagging allows the noninvasive assessment of the locally and temporally resolved motion pattern of the left ventricle. Alterations in cardiac torsion and diastolic relaxation of the left ventricle were studied in patients with aortic stenosis and were compared with those of healthy control subjects and championship rowers with physiological volume-overload hypertrophy.
METHODS AND RESULTS
Twelve aortic stenosis patients, 11 healthy control subjects with normal left ventricular function, and 11 world-championship rowers were investigated for systolic and diastolic heart wall motion on a basal and an apical level of the myocardium. Systolic torsion and untwisting during diastole were examined by use of a novel tagging technique (CSPAMM) that provides access to systolic and diastolic motion data. In the healthy heart, the left ventricle performs a systolic wringing motion, with a counterclockwise rotation at the apex and a clockwise rotation at the base. Apical untwisting precedes diastolic filling. In the athlete's heart, torsion and untwisting remain unchanged compared with those of the control subjects. In aortic stenosis patients, torsion is significantly increased and diastolic apical untwisting is prolonged compared with those of control subjects or athletes.
CONCLUSIONS
Torsional behavior as observed in pressure- and volume-overloaded hearts is consistent with current theoretical findings. A delayed diastolic untwisting in the pressure-overloaded hearts of the patients may contribute to a tendency toward diastolic dysfunction.
- Language
-
- English
- Open access status
- hybrid
- Identifiers
-
- DOI 10.1161/01.cir.100.4.361
- PMID 10421595
- Persistent URL
- https://folia.unifr.ch/global/documents/250616
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