Impact of reclassifying noninvasive follicular variant of papillary thyroid carcinoma on the risk of malignancy in The Bethesda System for Reporting Thyroid Cytopathology.
- Faquin WC Massachusetts General Hospital, Boston, Massachusetts.
- Wong LQ Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
- Afrogheh AH Massachusetts General Hospital, Boston, Massachusetts.
- Ali SZ Johns Hopkins Hospital, Baltimore, Maryland.
- Bishop JA Johns Hopkins Hospital, Baltimore, Maryland.
- Bongiovanni M Institute of Pathology, University Hospital, Lausanne, Switzerland.
- Pusztaszeri MP Geneva University Hospitals, Geneva, Switzerland.
- VandenBussche CJ Johns Hopkins Hospital, Baltimore, Maryland.
- Gourmaud J Institute of Pathology, University Hospital, Lausanne, Switzerland.
- Vaickus LJ Massachusetts General Hospital, Boston, Massachusetts.
- Baloch ZW Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
- 2015-10-13
Published in:
- Cancer cytopathology. - 2016
Bethesda
atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS)
fine-needle aspiration (FNA)
follicular variant
noninvasive
noninvasive follicular thyroid (NIFT)
papillary thyroid carcinoma
thyroid
Adenocarcinoma, Follicular
Adolescent
Adult
Aged
Aged, 80 and over
Biopsy, Fine-Needle
Carcinoma
Carcinoma, Papillary
Child
Female
Humans
Male
Middle Aged
Risk
Thyroid Cancer, Papillary
Thyroid Neoplasms
English
BACKGROUND
Recent discussions have focused on redefining noninvasive follicular variant of papillary thyroid carcinoma (NI-FVPTC) as a neoplasm rather than a carcinoma. This study assesses the potential impact of such a reclassification on the implied risk of malignancy (ROM) for the diagnostic categories of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC).
METHODS
The study consisted of consecutive fine-needle aspiration biopsy (FNAB) cases collected between January 1, 2013 and June 30, 2014 from 5 academic institutions. Demographic information, cytology diagnoses, and surgical pathology follow-up were recorded. The ROM was calculated with and without NI-FVPTC and was presented as a range: all cases (ie, overall risk of malignancy [OROM]) versus those with surgical follow-up only.
RESULTS
The FNAB cohort consisted of 6943 thyroid nodules representing 5179 women and 1409 men with an average age of 54 years (range, 9-94 years). The combined average ROM and OROM for the diagnostic categories of TBSRTC were as follows: nondiagnostic, 4.4% to 25.3%; benign, 0.9% to 9.3%; atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS), 12.1% to 31.2%; follicular neoplasm (FN), 21.8% to 33.2%; suspicious for malignancy (SM), 62.1% to 82.6%; and malignant, 75.9% to 99.1%. The impact of reclassifying NI-FVPTC on the ROM and OROM was most pronounced and statistically significant in the 3 indeterminate categories: the AUS/FLUS category had a decrease of 5.2% to 13.6%, the FN category had a decrease of 9.9% to 15.1%, and the SM category had a decrease of 17.6% to 23.4% (P < .05), whereas the benign and malignant categories had decreases of 0.3% to 3.5% and 2.5% to 3.3%, respectfully. The trend of the effect on the ROM and OROM was similar for all 5 institutions.
CONCLUSIONS
The results from this multi-institutional cohort indicate that the reclassification of NI-FVPTC will have a significant impact on the ROM for the 3 indeterminate categories of TBSRTC.
Recent discussions have focused on redefining noninvasive follicular variant of papillary thyroid carcinoma (NI-FVPTC) as a neoplasm rather than a carcinoma. This study assesses the potential impact of such a reclassification on the implied risk of malignancy (ROM) for the diagnostic categories of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC).
METHODS
The study consisted of consecutive fine-needle aspiration biopsy (FNAB) cases collected between January 1, 2013 and June 30, 2014 from 5 academic institutions. Demographic information, cytology diagnoses, and surgical pathology follow-up were recorded. The ROM was calculated with and without NI-FVPTC and was presented as a range: all cases (ie, overall risk of malignancy [OROM]) versus those with surgical follow-up only.
RESULTS
The FNAB cohort consisted of 6943 thyroid nodules representing 5179 women and 1409 men with an average age of 54 years (range, 9-94 years). The combined average ROM and OROM for the diagnostic categories of TBSRTC were as follows: nondiagnostic, 4.4% to 25.3%; benign, 0.9% to 9.3%; atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS), 12.1% to 31.2%; follicular neoplasm (FN), 21.8% to 33.2%; suspicious for malignancy (SM), 62.1% to 82.6%; and malignant, 75.9% to 99.1%. The impact of reclassifying NI-FVPTC on the ROM and OROM was most pronounced and statistically significant in the 3 indeterminate categories: the AUS/FLUS category had a decrease of 5.2% to 13.6%, the FN category had a decrease of 9.9% to 15.1%, and the SM category had a decrease of 17.6% to 23.4% (P < .05), whereas the benign and malignant categories had decreases of 0.3% to 3.5% and 2.5% to 3.3%, respectfully. The trend of the effect on the ROM and OROM was similar for all 5 institutions.
CONCLUSIONS
The results from this multi-institutional cohort indicate that the reclassification of NI-FVPTC will have a significant impact on the ROM for the 3 indeterminate categories of TBSRTC.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1002/cncy.21631
- PMID 26457584
- Persistent URL
- https://folia.unifr.ch/global/documents/249755
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