In vivo integrity of polymer-coated gold nanoparticles.
- Kreyling WG Institute of Lung Biology and Disease and Institute of Epidemiology 2, Helmholtz Zentrum München - German Research for Center for Environmental Health, Neuherberg/Munich 85764, Germany.
- Abdelmonem AM Department of Physics, Philipps Universität Marburg, Marburg 35032, Germany.
- Ali Z Department of Physics, Philipps Universität Marburg, Marburg 35032, Germany.
- Alves F 1] Department of Molecular Biology of Neuronal Signals, Max Planck Institute of Experimental Medicine, Göttingen 37075, Germany [2] Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen 37075, Germany.
- Geiser M Institute of Anatomy, University of Bern, Bern 3012, Switzerland.
- Haberl N Institute of Lung Biology and Disease and Institute of Epidemiology 2, Helmholtz Zentrum München - German Research for Center for Environmental Health, Neuherberg/Munich 85764, Germany.
- Hartmann R Department of Physics, Philipps Universität Marburg, Marburg 35032, Germany.
- Hirn S Institute of Lung Biology and Disease and Institute of Epidemiology 2, Helmholtz Zentrum München - German Research for Center for Environmental Health, Neuherberg/Munich 85764, Germany.
- de Aberasturi DJ 1] Department of Physics, Philipps Universität Marburg, Marburg 35032, Germany [2] Department of Inorganic Chemistry, UPV/EHU, Bilbao 48080, Spain; CIC-Energigune, Miñano 01510, Spain [3] CIC Biomagune, San Sebastian 20009, Spain.
- Kantner K Department of Physics, Philipps Universität Marburg, Marburg 35032, Germany.
- Khadem-Saba G Institute of Lung Biology and Disease and Institute of Epidemiology 2, Helmholtz Zentrum München - German Research for Center for Environmental Health, Neuherberg/Munich 85764, Germany.
- Montenegro JM Department of Physics, Philipps Universität Marburg, Marburg 35032, Germany.
- Rejman J Department of Physics, Philipps Universität Marburg, Marburg 35032, Germany.
- Rojo T Department of Inorganic Chemistry, UPV/EHU, Bilbao 48080, Spain; CIC-Energigune, Miñano 01510, Spain.
- de Larramendi IR Department of Inorganic Chemistry, UPV/EHU, Bilbao 48080, Spain; CIC-Energigune, Miñano 01510, Spain.
- Ufartes R Department of Molecular Biology of Neuronal Signals, Max Planck Institute of Experimental Medicine, Göttingen 37075, Germany.
- Wenk A Institute of Lung Biology and Disease and Institute of Epidemiology 2, Helmholtz Zentrum München - German Research for Center for Environmental Health, Neuherberg/Munich 85764, Germany.
- Parak WJ 1] Department of Physics, Philipps Universität Marburg, Marburg 35032, Germany [2] CIC Biomagune, San Sebastian 20009, Spain.
- 2015-06-16
Published in:
- Nature nanotechnology. - 2015
Animals
Coated Materials, Biocompatible
Female
Gold
Metal Nanoparticles
Organ Specificity
Particle Size
Polymers
Rats
Rats, Inbred WKY
Tissue Distribution
Viscera
English
Inorganic nanoparticles are frequently engineered with an organic surface coating to improve their physicochemical properties, and it is well known that their colloidal properties may change upon internalization by cells. While the stability of such nanoparticles is typically assayed in simple in vitro tests, their stability in a mammalian organism remains unknown. Here, we show that firmly grafted polymer shells around gold nanoparticles may degrade when injected into rats. We synthesized monodisperse radioactively labelled gold nanoparticles ((198)Au) and engineered an (111)In-labelled polymer shell around them. Upon intravenous injection into rats, quantitative biodistribution analyses performed independently for (198)Au and (111)In showed partial removal of the polymer shell in vivo. While (198)Au accumulates mostly in the liver, part of the (111)In shows a non-particulate biodistribution similar to intravenous injection of chelated (111)In. Further in vitro studies suggest that degradation of the polymer shell is caused by proteolytic enzymes in the liver. Our results show that even nanoparticles with high colloidal stability can change their physicochemical properties in vivo.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1038/nnano.2015.111
- PMID 26076469
- Persistent URL
- https://folia.unifr.ch/global/documents/247213
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