Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

• Christophersen IE Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Rienstra M Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
• Roselli C Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Yin X NHLBI and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
• Geelhoed B Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
• Barnard J Departments of Cardiovascular Medicine, Cellular and Molecular Medicine, Molecular Cardiology, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
• Lin H NHLBI and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
• Arking DE McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
• Smith AV Icelandic Heart Association, Kopavogur, Iceland.
• Albert CM Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
• Chaffin M Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Tucker NR Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Li M Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
• Klarin D Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Bihlmeyer NA Predoctoral Training Program in Human Genetics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
• Low SK Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
• Weeke PE Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
• Müller-Nurasyid M Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
• Smith JG Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Brody JA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
• Niemeijer MN Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
• Dörr M Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
• Trompet S Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
• Huffman J MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
• Gustafsson S Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
• Schurmann C Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
• Kleber ME Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
• Lyytikäinen LP Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
• Seppälä I Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
• Malik R Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany.
• Horimoto ARVR Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil.
• Perez M Department of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
• Sinisalo J Heart and Lung Center HUS, Helsinki University Central Hospital, Helsinki, Finland.
• Aeschbacher S Department of Medicine, University Hospital Basel, Basel, Switzerland.
• Thériault S Population Health Research Institute, Hamilton, Ontario, Canada.
• Yao J Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
• Radmanesh F Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Weiss S DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
• Teumer A DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
• Choi SH Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Weng LC Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Clauss S Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
• Deo R Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
• Rader DJ Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
• Shah SH Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
• Sun A Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
• Hopewell JC CTSU-Nuffield Department of Population Health, University of Oxford, Oxford, UK.
• Debette S INSERM U1219 (Bordeaux Population Health Centre), Bordeaux, France.
• Chauhan G INSERM U1219 (Bordeaux Population Health Centre), Bordeaux, France.
• Yang Q Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
• Worrall BB Departments of Neurology and Public Health Science, University of Virginia Health System, Charlottesville, Virginia, USA.
• Paré G Population Health Research Institute, Hamilton, Ontario, Canada.
• Kamatani Y Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
• Hagemeijer YP Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
• Verweij N Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
• Siland JE Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
• Kubo M RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
• Smith JD Departments of Cardiovascular Medicine, Cellular and Molecular Medicine, Molecular Cardiology, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
• Van Wagoner DR Departments of Cardiovascular Medicine, Cellular and Molecular Medicine, Molecular Cardiology, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
• Bis JC Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
• Perz S Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
• Psaty BM Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
• Ridker PM Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
• Magnani JW NHLBI and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
• Harris TB Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA.
• Launer LJ Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA.
• Shoemaker MB Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
• Padmanabhan S Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
• Haessler J Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA.
• Bartz TM Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
• Waldenberger M DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
• Lichtner P Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
• Arendt M Institute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.
• Krieger JE Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil.
• Kähönen M Department of Clinical Physiology, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland.
• Risch L University Institute of Clinical Chemistry, University of Bern, Bern, Switzerland.
• Mansur AJ Heart Institute, University of São Paulo, São Paulo, Brazil.
• Peters A DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
• Smith BH Division of Population Health Sciences, University of Dundee, Dundee, UK.
• Lind L Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
• Scott SA Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
• Lu Y Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
• Bottinger EB Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
• Hernesniemi J Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
• Lindgren CM Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
• Wong JA Division of Cardiology, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
• Huang J Boston VA Research Institute, Inc., Boston, Massachusetts, USA.
• Eskola M Department of Cardiology, Heart Hospital, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland.
• Morris AP Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
• Ford I Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK.
• Reiner AP Department of Epidemiology, University of Washington, Seattle, Washington, USA.
• Delgado G Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
• Chen LY Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
• Chen YI Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
• Sandhu RK Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada.
• Li M Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.
• Boerwinkle E Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.
• Eisele L Institute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.
• Lannfelt L Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
• Rost N Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Anderson CD Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Taylor KD Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
• Campbell A Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
• Magnusson PK Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
• Porteous D Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
• Hocking LJ Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen, UK.
• Vlachopoulou E Transplantation Laboratory, Medicum, University of Helsinki, Helsinki, Finland.
• Pedersen NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
• Nikus K Department of Cardiology, Heart Hospital, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland.
• Orho-Melander M Department of Clinical Sciences, Lund University, Malmö, Sweden.
• Hamsten A Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
• Heeringa J Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
• Denny JC Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
• Kriebel J Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
• Darbar D Department of Medicine and Pharmacology, University of Illinois, Chicago, Illinois, USA.
• Newton-Cheh C Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Shaffer C Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
• Macfarlane PW Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
• Heilmann-Heimbach S Institute of Human Genetics, University of Bonn, Bonn, Germany.
• Almgren P Department of Clinical Sciences, Lund University, Malmö, Sweden.
• Huang PL Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
• Sotoodehnia N Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA.
• Soliman EZ Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
• Uitterlinden AG Department of Epidemiology and Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
• Hofman A Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
• Franco OH Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
• Völker U DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
• Jöckel KH Institute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.
• Sinner MF Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Munich, Germany.
• Lin HJ Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
• Guo X Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
• Dichgans M Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA.
• Ingelsson E Department of Internal Medicine, Clinical Sciences, Lund University, Malmö, Sweden.
• Kooperberg C Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
• Melander O Department of Cardio-Thoracic Surgery, Heart Hospital, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland.
• Loos RJF Department of Medicine, University Hospital Basel, Basel, Switzerland.
• Laurikka J Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Conen D Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
• Rosand J Transplantation Laboratory, Medicum, University of Helsinki, Helsinki, Finland.
• van der Harst P Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Lokki ML Laboratory of Genetics and Molecular Biology, Heart Institute, University of São Paulo, São Paulo, Brazil.
• Kathiresan S Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
• Pereira A MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
• Jukema JW Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
• Hayward C Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
• Rotter JI Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
• März W Department of Epidemiology and Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
• Lehtimäki T Departments of Cardiovascular Medicine, Cellular and Molecular Medicine, Molecular Cardiology, and Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
• Stricker BH Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
• Chung MK Icelandic Heart Association, Kopavogur, Iceland.
• Felix SB Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
• Gudnason V Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
• Alonso A Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Munich, Germany.
• Roden DM Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Kääb S Department of Epidemiology, University of Washington, Seattle, Washington, USA.
• Chasman DI NHLBI and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
• Heckbert SR Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
• Benjamin EJ NHLBI and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
• Tanaka T Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Lunetta KL Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
• Lubitz SA
• Ellinor PT

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African Americans

Atrial Fibrillation

European Continental Ancestry Group

Genetic Loci

Genetic Predisposition to Disease

Genome-Wide Association Study

Humans

Quantitative Trait Loci