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Atypical presentation of acute myeloid leukemia: cardiac myeloid sarcoma.
Journal article

Atypical presentation of acute myeloid leukemia: cardiac myeloid sarcoma.

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  • 2009-04-24
Published in:
  • International journal of hematology. - 2009
Cardiomegaly
Fatal Outcome
Heart Neoplasms
Humans
Immunophenotyping
Leukemia, Myeloid, Acute
Male
Middle Aged
Pleural Effusion
Remission Induction
Sarcoma, Myeloid
Shock, Septic
English We present the case of a 52-year-old man with a 2-month history of dyspnea, bilateral pleural effusion and cardiomegaly of rapid onset. A cardiac ultrasound showed pericardial effusion with infiltration of the infero-lateral cardiac wall, right auricle and aortic arch by a mass of unknown origin. Despite 1% blast cells in the peripheral blood, 2 bone marrow biopsies were negative for malignancy. Flow cytometry analysis of the blood and immunohistochemistry study of the pleural liquid showed a blast population of CD34+, CD33+, CD13+ and HLA-DR+ cells; a percutaneous cardiac biopsy showed CD34+ cells in the pericardium which led to the diagnosis of extramedullary acute myeloid leukemia (AML). The patient was treated with induction chemotherapy allowing remission, but unfortunately died of septic shock of fungal origin. This case illustrates a rare presentation of cardiac extramedullary AML.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/245214
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