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Journal article

Yet another numbering scheme for immunoglobulin variable domains: an automatic modeling and analysis tool.

  • Honegger A Biochemisches Institut der Universität Zürich, Winterthurerstrasse 190, Zürich, CH-8057, Switzerland. honegger@bioc.unizh.ch
  • Plückthun A
  • 2001-06-09
Published in:
  • Journal of molecular biology. - 2001
Amino Acid Sequence
Animals
Automation
Complementarity Determining Regions
Computational Biology
Databases as Topic
Humans
Immunoglobulin Variable Region
Models, Molecular
Molecular Sequence Data
Protein Engineering
Protein Structure, Tertiary
Reproducibility of Results
Sequence Alignment
Software
Terminology as Topic
English A common residue numbering scheme for all immunoglobulin variable domains (immunoglobulin light chain lambda (V(lambda)) and kappa (V(kappa)) variable domains, heavy chain variable domains (V(H)) and T-cell receptor alpha (V(alpha)), beta (V(beta)), gamma (V(gamma)) and delta (V(delta)) variable domains) has been devised. Based on the spatial alignment of known three-dimensional structures of immunoglobulin domains, it places the alignment gaps in a way that minimizes the average deviation from the averaged structure of the aligned domains. This residue numbering scheme was applied to the immunoglobulin variable domain structures in the PDB database to automate the extraction of information on structural variations in homologous positions of the different molecules. A number of methods are presented that allow the automated projection of information derived from individual structures or from the comparison of multi-structure alignments onto a graphical representation of the sequence alignment.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/243629
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