Targeting Arousal and Sleep through Noninvasive Brain Stimulation to Improve Mental Health.
- Geiser T University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
- Hertenstein E University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
- Fehér K University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
- Maier JG University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
- Schneider CL University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
- Züst MA University Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
- Wunderlin M University Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
- Mikutta C University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
- Klöppel S University Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
- Nissen C University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland, christoph.nissen@upd.ch.
- 2020-05-15
Published in:
- Neuropsychobiology. - 2020
Auditory stimulation
Direct current stimulation
Sleep spindles
Slow-wave sleep
Transcranial magnetic stimulation
English
Arousal and sleep represent fundamental physiological domains, and alterations in the form of insomnia (difficulty falling or staying asleep) or hypersomnia (increased propensity for falling asleep or increased sleep duration) are prevalent clinical problems. Current first-line treatments include psychotherapy and pharmacotherapy. Despite significant success, a number of patients do not benefit sufficiently. Progress is limited by an incomplete understanding of the -neurobiology of insomnia and hypersomnia. This work summarizes current concepts of the regulation of arousal and sleep and its modulation through noninvasive brain stimulation (NIBS), including transcranial magnetic, current, and auditory stimulation. Particularly, we suggest: (1) characterization of patients with sleep problems - across diagnostic entities of mental disorders - based on specific alterations of sleep, including alterations of sleep slow waves, sleep spindles, cross-frequency coupling of brain oscillations, local sleep-wake regulation, and REM sleep and (2) targeting these with specific NIBS techniques. While evidence is accumulating that the modulation of specific alterations of sleep through NIBS is feasible, it remains to be tested whether this translates to clinically relevant effects and new treatment developments.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1159/000507372
- PMID 32408296
- Persistent URL
- https://folia.unifr.ch/global/documents/242019
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