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Mitochondria: from cell death executioners to regulators of cell differentiation.
Journal article

Mitochondria: from cell death executioners to regulators of cell differentiation.

  • Kasahara A Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.
  • Scorrano L Department of Biology, University of Padua, 35121 Padua, Italy; Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, 35129 Padua, Italy. Electronic address: luca.scorrano@unipd.it.
  • 2014-09-06
Published in:
  • Trends in cell biology. - 2014
Ca(2+)
DRP1
MFN
Notch signaling
OPA1
cardiomyocyte
differentiation
hair follicle
heart
mitochondrial dynamics
Apoptosis
Autophagy
Cell Differentiation
Energy Metabolism
Humans
Microtubule-Associated Proteins
Mitochondria
Mitochondrial Dynamics
Mitochondrial Membranes
Signal Transduction
English Most, if not all mitochondrial functions, including adenosine-5'-triphosphate (ATP) production and regulation of apoptosis and Ca(2+) homeostasis, are inextricably linked to mitochondrial morphology and dynamics, a process controlled by a family of GTP-dependent dynamin related 'mitochondria-shaping' proteins. Mitochondrial fusion and fission directly influence mitochondrial metabolism, apoptotic and necrotic cell death, autophagy, muscular atrophy and cell migration. In this review, we discuss the recent evidence indicating that mitochondrial dynamics influence complex signaling pathways, affect gene expression and define cell differentiation. These findings extend the importance of mitochondria to developmental biology, far beyond their mere bioenergetic role.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/240576
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