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Bone alkaline phosphatase in rheumatic diseases.
Journal article

Bone alkaline phosphatase in rheumatic diseases.

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  • 1995-07-01
Published in:
  • Annals of clinical biochemistry. - 1995
Adult
Age Distribution
Aged
Aged, 80 and over
Alkaline Phosphatase
Arthritis, Rheumatoid
Bone and Bones
Female
Humans
Immunoradiometric Assay
Male
Middle Aged
Sex Distribution
Spondylitis, Ankylosing
English A double monoclonal immunoradiometric assay specific for bone alkaline phosphatase (BAP) was used to determine whether the raised total alkaline phosphatase (TAP) often found in patients with active rheumatoid arthritis (RA) and ankylosing spondylitis (AS) is derived from bone or liver. Fifty-eight patients with RA were compared to 14 with AS and 14 with non-inflammatory rheumatic diseases (NI). None had clinical liver disease and only one had a slightly elevated aspartate transaminase activity. Elevated BAP concentrations were found in seven patients (5 RA, 1 AS, 1 NI), only two of whom also had abnormal TAP. Abnormal TAP activities were found in only three patients (all RA). BAP did not correlate with disease activity in RA or AS. In contrast, TAP correlated with disease activity (assessed by plasma viscosity) in RA (P < 0.002) and gamma-glutamyl transferase (GGT) also correlated with plasma viscosity in RA (P < 0.01). Both TAP and BAP were significantly correlated with GGT in RA (P < 0.001 and P < 0.02, respectively). These findings are discussed, together with possible reasons for the conflicting nature of some of the observations.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/237482
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