Journal article
Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990–2017
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Yadgir, Simon
Institute for Health Metrics and Evaluation (S.Y., C.O.J., C.M.B., S.I.H., A.H.M., M.R.N., G.A.R.), University of Washington, Seattle.
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Johnson, Catherine Owens
Institute for Health Metrics and Evaluation (S.Y., C.O.J., C.M.B., S.I.H., A.H.M., M.R.N., G.A.R.), University of Washington, Seattle.
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Aboyans, Victor
Institute of Epidemiology, University of Limoges, France (V. Aboyans).
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Adebayo, Oladimeji M.
College of Medicine, University College Hospital, College of Medicine, University College Hospital, Ibadan, Oyo, Nigeria (O.M.A.).
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Adedoyin, Rufus Adesoji
Department of Medical Rehabilitation, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria (R.A.A.).
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Afarideh, Mohsen
Endocrinology and Metabolism Research Center (M.A., A.E.), Tehran University of Medical Sciences, Iran.
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Alahdab, Fares
Evidence Based Practice Center, Mayo Clinic Foundation for Medical Education and Research, Rochester, MN (F.A.).
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Alashi, Alaa
Department of Cardiovascular Medicine (A.A., M.M.G.), Cleveland Clinic, OH.
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Alipour, Vahid
Health Economics Department (V. Alipour), Iran University of Medical Sciences, Tehran.
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Arabloo, Jalal
Health Management and Economics Research Center (V. Alipour, J.A., S.A., A. Rezapour), Iran University of Medical Sciences, Tehran.
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Azari, Samad
Health Management and Economics Research Center (V. Alipour, J.A., S.A., A. Rezapour), Iran University of Medical Sciences, Tehran.
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Barthelemy, Celine M.
Institute for Health Metrics and Evaluation (S.Y., C.O.J., C.M.B., S.I.H., A.H.M., M.R.N., G.A.R.), University of Washington, Seattle.
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Benziger, Catherine P.
Heart and Vascular Center, Essentia Health, Duluth, MN (C.P.B.).
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Berman, Adam E.
Department of Medicine, Medical College of Georgia at Augusta University (A.E.B.).
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Bijani, Ali
Social Determinants of Health Research Center, Babol University of Medical Sciences, Mazandaran, Iran (A.B.).
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Carrero, Juan J.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (J.J.C.).
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Carvalho, Félix
Institute of Public Health (F.C.), University of Porto, Portugal.
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Daryani, Ahmad
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Durães, Andre R.
School of Medicine, Federal University of Bahia, Salvador, Brazil (A.R.D.).
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Esteghamati, Alireza
Endocrinology and Metabolism Research Center (M.A., A.E.), Tehran University of Medical Sciences, Iran.
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Farid, Talha A.
Division of Cardiovascular Medicine, University of Louisville, KY (T.A.F., A.R.K.).
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Farzadfar, Farshad
Non-communicable Diseases Research Center (F.F.), Tehran University of Medical Sciences, Iran.
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Fernandes, Eduarda
REQUIMTE/LAQV (E.F.), University of Porto, Portugal.
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Filip, Irina
Department of Health Sciences, A.T. Still University, Mesa, AZ (I.F.).
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Gad, Mohamed M.
Gillings School of Global Public Health, University of North Carolina Chapel Hill (M.M.G.).
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Hamidi, Samer
School of Health and Environmental Studies, Hamdan Bin Mohammed Smart University, Dubai, United Arab Emirates (S.H.).
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Hay, Simon I.
Department of Cardiology, Dupuytren University Hospital, Limoges, France (V. Aboyans).
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Ilesanmi, Olayinka Stephen
Department of Community Medicine, University of Ibadan, Nigeria (O.S.I.).
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Naghibi Irvani, Seyed Sina
Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran (S.S.N.I.).
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Jürisson, Mikk
Institute of Family Medicine and Public Health, University of Tartu, Tartumaa, Estonia (M.J.).
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Kasaeian, Amir
Hematologic Malignancies Research Center (A. Kasaeian), Tehran University of Medical Sciences, Iran.
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Kengne, Andre Pascal
Department of Medicine, University of Cape Town, South Africa (A.P.K., G.A.M., K.S.).
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Khan, Abdur Rahman
Division of Cardiovascular Medicine, University of Louisville, KY (T.A.F., A.R.K.).
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Kisa, Adnan
Department of Health Services Policy and Management, University of South Carolina, Columbia (A. Kisa).
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Kisa, Sezer
Department of Nursing and Health Promotion, Oslo Metropolitan University, Norway (S.K.).
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Kolte, Dhaval
Department of Medicine, Brown University, Providence, RI (D.K.).
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Manafi, Navid
Ophthalmology Department, University of Manitoba, Winnipeg, Canada (N.M.).
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Manafi, Amir
Department of Surgery, University of Virginia, Charlottesville (A.M.).
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Mensah, George A.
Center for Translation Research and Implementation Science, National Institutes of Health, Bethesda, MD (G.A.M.).
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Mirrakhimov, Erkin M.
Department of Atherosclerosis and Coronary Heart Disease, National Center of Cardiology and Internal Disease, Bishkek, Kyrgyzstan (E.M.M.).
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Mohammad, Yousef
Internal Medicine Department, King Saud University, Riyadh, Saudi Arabia (Y.M.).
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Mokdad, Ali H.
Department of Health Metrics Sciences (A.H.M., G.A.R.), University of Washington, Seattle.
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Negoi, Ruxandra Irina
Department of Cardiology, Cardio-Aid, Bucharest, Romania (R.I.N.).
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Thi Nguyen, Huong Lan
Institute for Global Health Innovations, Duy Tan University, Hanoi, Vietnam (H.L.T.N.).
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Nguyen, Trang Huyen
Center of Excellence in Behavioral Health, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam (T.H.N.).
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Nixon, Molly R.
Institute for Health Metrics and Evaluation (S.Y., C.O.J., C.M.B., S.I.H., A.H.M., M.R.N., G.A.R.), University of Washington, Seattle.
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Otto, Catherine M.
Division of Cardiology (C.M.O., G.A.R.), University of Washington, Seattle.
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Patel, Shanti
Department of Medicine, Maimonides Medical Center, Brooklyn, NY (S.P.).
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Pilgrim, Thomas
Department of Cardiology, University of Bern, Switzerland (T.P.).
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Radfar, Amir
Medichem, Barcelona, Spain (A. Radfar).
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Rawaf, David Laith
University College London Hospitals, United Kingdom (D.L.R.).
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Rawaf, Salman
Public Health England, London, United Kingdom (S.R.).
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Rawasia, Wasiq Faraz
Cardiovascular Medicine, West Virginia University, Morgantown (W.F.R.).
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Rezapour, Aziz
Health Management and Economics Research Center (V. Alipour, J.A., S.A., A. Rezapour), Iran University of Medical Sciences, Tehran.
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Roever, Leonardo
Department of Clinical Research, Federal University of Uberl ândia, Brazil (L.R.).
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Saad, Anas M.
Faculty of Medicine, Ain Shams University, Cairo, Egypt (A.M.S.).
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Saadatagah, Seyedmohammad
Department of Cardiology (S. Saadatagah), Tehran University of Medical Sciences, Iran.
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Senthilkumaran, Subramanian
Emergency Department, Manian Medical Centre, ERODE, Tamil Nadu, India (S. Senthilkumaran).
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Sliwa, Karen
Department of Medicine, University of Cape Town, South Africa (A.P.K., G.A.M., K.S.).
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Tesfay, Berhe Etsay
Department of Public Health, Adigrat University, Tigray, Ethiopia (B.E.T.).
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Tran, Bach Xuan
Department of Health Economics, Hanoi Medical University, Vietnam (B.X.T.).
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Ullah, Irfan
TB Culture Laboratory, Mufti Mehmood Memorial Teaching Hospital, Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan (I.U.).
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Vaduganathan, Muthiah
Heart and Vascular Center, Harvard University, Boston, MA (M.V.).
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Vasankari, Tommi Juhani
UKK Institute, Tampere, Finland (T.J.V.).
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Wolfe, Charles D.A.
Biomedical Research Council, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom (C.D.A.W.).
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Yonemoto, Naohiro
Department of Psychopharmacology, National Center of Neurology and Psychiatry, Tokyo, Japan (N.Y.).
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Roth, Gregory A.
Division of Cardiology (C.M.O., G.A.R.), University of Washington, Seattle.
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Published in:
- Circulation. - Ovid Technologies (Wolters Kluwer Health). - 2020, vol. 141, no. 21, p. 1670-1680
English
Background:
Nonrheumatic valvular diseases are common; however, no studies have estimated their global or national burden. As part of the Global Burden of Disease Study 2017, mortality, prevalence, and disability-adjusted life-years (DALYs) for calcific aortic valve disease (CAVD), degenerative mitral valve disease, and other nonrheumatic valvular diseases were estimated for 195 countries and territories from 1990 to 2017.
Methods:
Vital registration data, epidemiologic survey data, and administrative hospital data were used to estimate disease burden using the Global Burden of Disease Study modeling framework, which ensures comparability across locations. Geospatial statistical methods were used to estimate disease for all countries, because data on nonrheumatic valvular diseases are extremely limited for some regions of the world, such as Sub-Saharan Africa and South Asia. Results accounted for estimated level of disease severity as well as the estimated availability of valve repair or replacement procedures. DALYs and other measures of health-related burden were generated for both sexes and each 5-year age group, location, and year from 1990 to 2017.
Results:
Globally, CAVD and degenerative mitral valve disease caused 102 700 (95% uncertainty interval [UI], 82 700–107 900) and 35 700 (95% UI, 30 500–42 500) deaths, and 12.6 million (95% UI, 11.4 million–13.8 million) and 18.1 million (95% UI, 17.6 million–18.6 million) prevalent cases existed in 2017, respectively. A total of 2.5 million (95% UI, 2.3 million–2.8 million) DALYs were estimated as caused by nonrheumatic valvular diseases globally, representing 0.10% (95% UI, 0.09%–0.11%) of total lost health from all diseases in 2017. The number of DALYs increased for CAVD and degenerative mitral valve disease between 1990 and 2017 by 101% (95% UI, 79%–117%) and 35% (95% UI, 23%–47%), respectively. There is significant geographic variation in the prevalence, mortality rate, and overall burden of these diseases, with highest age-standardized DALY rates of CAVD estimated for high-income countries.
Conclusions:
These global and national estimates demonstrate that CAVD and degenerative mitral valve disease are important causes of disease burden among older adults. Efforts to clarify modifiable risk factors and improve access to valve interventions are necessary if progress is to be made toward reducing, and eventually eliminating, the burden of these highly treatable diseases.
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Language
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Open access status
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closed
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Identifiers
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Persistent URL
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https://folia.unifr.ch/global/documents/234892
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