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Quantitative high-throughput analysis of drugs in biological matrices by mass spectrometry.
Journal article

Quantitative high-throughput analysis of drugs in biological matrices by mass spectrometry.

  • Hopfgartner G University of Geneva, School of Pharmacy, Laboratory of Pharmaceutical Analytical Chemistry, Life Sciences Mass Spectrometry, 20 Bd d'Yvoy, CH-1211 Geneva 4, Switzerland.
  • Bourgogne E
  • 2003-07-03
Published in:
  • Mass spectrometry reviews. - 2003
Animals
Blood
Drug Evaluation
Drug Evaluation, Preclinical
Humans
Mass Spectrometry
Pharmaceutical Preparations
Pharmacokinetics
Urine
English To support pharmacokinetic and drug metabolism studies, LC-MS/MS plays more and more an essential role for the quantitation of drugs and their metabolites in biological matrices. With the new challenges encountered in drug discovery and drug development, new strategies are put in place to achieve high-throughput analysis, using serial and parallel approaches. To speed-up method development and validation, generic approaches with the direct injection of biological fluids is highly desirable. Column-switching, using various packing materials for the extraction columns, is widely applied. Improvement of mass spectrometers performance, and in particular triple quadrupoles, also strongly influences sample preparation strategies, which remain a key element in the bioanalytical process.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/230428
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