Journal article
Automated capillary electrophoresis with on-line preconcentration by solid phase extraction using a sequential injection manifold and contactless conductivity detection.
- Mai TD University of Basel, Department of Chemistry, Spitalstrasse 51, 4056 Basel, Switzerland.
- Bomastyk B
- Duong HA
- Pham HV
- Hauser PC
- 2012-05-01
Published in:
- Analytica chimica acta. - 2012
English
An extension of a capillary electrophoresis instrument coupled to a sequential injection analysis manifold was developed for automated measurements with on-line solid-phase extraction preconcentration. An in-house built capacitively coupled contactless conductivity detector was employed for sensitive detection with narrow capillaries of 25 μm internal diameter. The system was assembled into standardized 19 in. frames and racks for easy transport and mobile deployment. The system can be left running unattendedly without manual intervention with good operation stability. To demonstrate the application of the system, a method for the determination of four drugs, namely ibuprofen, diclofenac, naproxen and bezafibrate, was developed with enrichment factors of up to several hundreds. Detection of the drug residues down to the nM-scale was found possible and the method was found suitable for the detection of ibuprofen in the waste water of a hospital in Hanoi.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.aca.2012.03.035
- PMID 22541815
- Persistent URL
- https://folia.unifr.ch/global/documents/228132
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