Journal article
Co-occurrence of neuroblastoma and nephroblastoma in an infant with Fanconi's anemia.
- Bissig H Division of Hematology/Oncology, University Children's Hospital Basel, Basel, Switzerland.
- Staehelin F
- Tolnay M
- Avoledo P
- Richter J
- Betts D
- Bruder E
- Kühne T
- 2002-10-24
Published in:
- Human pathology. - 2002
Brain Neoplasms
Chromosomes, Human, Pair 17
Fanconi Anemia
Humans
Infant, Newborn
Kidney Neoplasms
Neuroblastoma
Wilms Tumor
English
We report the clinical, histologic, and genetic findings of concurrent neuroblastoma and nephroblastoma in an infant with Fanconi's anemia (FA). Both tumors had characteristic chromosomal aberrations. In particular, the neuroblastoma showed a gain of chromosome 17q, considered an important factor for prognosis. But untypical genetic changes were also seen suggesting that FA as a chromosomal instability syndrome causes new and untypical chromosomal variations in different tumors. The present case is unique because the simultaneous occurrence of a neuroblastoma and nephroblastoma with FA has not yet been described.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1053/hupa.2002.128062
- PMID 12395380
- Persistent URL
- https://folia.unifr.ch/global/documents/227801
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