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Mild complexation protocol for chiral CpxRh and Ir complexes suitable for in situ catalysis.
Journal article

Mild complexation protocol for chiral CpxRh and Ir complexes suitable for in situ catalysis.

  • Audic B Laboratory of Asymmetric Catalysis and Synthesis , EPFL SB ISIC LCSA, BCH 4305 , CH-1015 Lausanne , Switzerland . Email: nicolai.cramer@epfl.ch.
  • Wodrich MD Laboratory for Computational Molecular Design , EPFL SB ISIC LCMD, BCH 5312 , CH-1015 Lausanne , Switzerland . Email: matthew.wodrich@epfl.ch.
  • Cramer N Laboratory of Asymmetric Catalysis and Synthesis , EPFL SB ISIC LCSA, BCH 4305 , CH-1015 Lausanne , Switzerland . Email: nicolai.cramer@epfl.ch.
  • 2019-02-19
Published in:
  • Chemical science. - 2019
General Chemistry
English A practical complexation method for chiral cyclopentadienyl (Cpx) iridium and rhodium complexes is described. The procedure uses the free CpxH with stable and commercially available rhodium(i) and iridium(i) salts without base or additive. The conditions are mild and do not require the exclusion of air and moisture. A salient feature is the suitability for in situ complexations enhancing the user-friendliness of Cpx ligands in asymmetric catalysis. DFT-calculations confirm an intramolecular proton abstraction pathway by either the bound acetate or methoxide. Furthermore, the superior facial selectivity of the proton abstraction step enabled the development of TMS-containing trisubstituted Cpx ligands which display improved enantioselectivities for the benchmarking dihydroisoquinolone synthesis.
Language
  • English
Open access status
gold
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Persistent URL
https://folia.unifr.ch/global/documents/225960
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