Mechanism of action of 5-nitrothiophenes against Mycobacterium tuberculosis.
- Hartkoorn RC Ecole Polytechnique Fédérale de Lausanne, Global Health Institute, Lausanne, Switzerland.
- Ryabova OB
- Chiarelli LR
- Riccardi G
- Makarov V
- Cole ST
- 2014-02-20
Published in:
- Antimicrobial agents and chemotherapy. - 2014
English
On using the streptomycin-starved 18b strain as a model for nonreplicating Mycobacterium tuberculosis, we identified a 5-nitrothiophene compound as highly active but not cytotoxic. Mutants resistant to 5-nitrothiophenes were found be cross-resistant to the nitroimidazole PA-824 and unable to produce the F420 cofactor. Furthermore, 5-nitrothiophenes were shown to be activated by the F420-dependent nitroreductase Ddn and to release nitric oxide, a mechanism of action identical to that described for nitroimidazoles.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1128/AAC.02693-13
- PMID 24550336
- Persistent URL
- https://folia.unifr.ch/global/documents/225751
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