Journal article
Levels of saliva cotinine in electronic cigarette users.
- Etter JF Institute of Global Health, Faculty of Medicine, University of Geneva, Geneva 4, Switzerland.
- 2014-01-10
Published in:
- Addiction (Abingdon, England). - 2014
Electronic cigarette
Internet survey
electronic nicotine delivery system (ENDS)
nicotine
smoking
tobacco
Adult
Cotinine
Electronic Nicotine Delivery Systems
Female
Humans
Male
Middle Aged
Nicotine
Nicotinic Agonists
Saliva
Smoking
Tobacco Products
English
AIMS
To assess saliva cotinine levels in experienced users of e-cigarettes ('vapers').
DESIGN, SETTING AND PARTICIPANTS
An internet survey in 2011 and 2012, with collection of saliva vials by mail. Participants were 71 users of e-cigarettes enrolled mainly on websites and online forums dedicated to e-cigarettes.
MEASUREMENTS
Use of e-cigarettes, tobacco and nicotine medications. Collection of saliva by mail and analysis of cotinine by liquid chromatography-mass spectrometry.
FINDINGS
Most participants (89%) were former smokers, most (92%) were using e-cigarettes daily, had been using e-cigarettes for 12 months on average and puffed a median of 150 times per day on their e-cigarettes [mean = 220 puffs/day, 95% confidence interval (CI) = 169-271]. The median concentration of nicotine in refill liquids was 16 mg/ml (mean = 16.4, 95% CI = 14.5-18.3). In the 62 e-cigarette users who, in the past 5 days, had not used any tobacco or nicotine medications, the median cotinine level was 353 ng/ml (mean = 374, 95% CI = 318-429), the correlation between cotinine and nicotine concentration in e-liquids was r = 0.33 (P = 0.013), and the correlation between cotinine and the number of cigarettes smoked per day before quitting smoking was r = 0.48 (P < 0.001).
CONCLUSIONS
At least some experienced users of electronic cigarettes appear to be able to gain as much nicotine from those products as do cigarette smokers.
To assess saliva cotinine levels in experienced users of e-cigarettes ('vapers').
DESIGN, SETTING AND PARTICIPANTS
An internet survey in 2011 and 2012, with collection of saliva vials by mail. Participants were 71 users of e-cigarettes enrolled mainly on websites and online forums dedicated to e-cigarettes.
MEASUREMENTS
Use of e-cigarettes, tobacco and nicotine medications. Collection of saliva by mail and analysis of cotinine by liquid chromatography-mass spectrometry.
FINDINGS
Most participants (89%) were former smokers, most (92%) were using e-cigarettes daily, had been using e-cigarettes for 12 months on average and puffed a median of 150 times per day on their e-cigarettes [mean = 220 puffs/day, 95% confidence interval (CI) = 169-271]. The median concentration of nicotine in refill liquids was 16 mg/ml (mean = 16.4, 95% CI = 14.5-18.3). In the 62 e-cigarette users who, in the past 5 days, had not used any tobacco or nicotine medications, the median cotinine level was 353 ng/ml (mean = 374, 95% CI = 318-429), the correlation between cotinine and nicotine concentration in e-liquids was r = 0.33 (P = 0.013), and the correlation between cotinine and the number of cigarettes smoked per day before quitting smoking was r = 0.48 (P < 0.001).
CONCLUSIONS
At least some experienced users of electronic cigarettes appear to be able to gain as much nicotine from those products as do cigarette smokers.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1111/add.12475
- PMID 24401004
- Persistent URL
- https://folia.unifr.ch/global/documents/224736
Statistics
Document views: 10
File downloads: