Base-calling for next-generation sequencing platforms.
- Ledergerber C ETH Zurich, Switzerland.
- Dessimoz C
- 2011-01-20
Published in:
- Briefings in bioinformatics. - 2011
English
Next-generation sequencing platforms are dramatically reducing the cost of DNA sequencing. With these technologies, bases are inferred from light intensity signals, a process commonly referred to as base-calling. Thus, understanding and improving the quality of sequence data generated using these approaches are of high interest. Recently, a number of papers have characterized the biases associated with base-calling and proposed methodological improvements. In this review, we summarize recent development of base-calling approaches for the Illumina and Roche 454 sequencing platforms.
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1093/bib/bbq077
- PMID 21245079
- Persistent URL
- https://folia.unifr.ch/global/documents/223027
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