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Home-based HPV self-sampling assisted by a cloud-based electronic data system: Lessons learnt from a pilot community cervical cancer screening campaign in rural Ethiopia.
Journal article

Home-based HPV self-sampling assisted by a cloud-based electronic data system: Lessons learnt from a pilot community cervical cancer screening campaign in rural Ethiopia.

  • Jede F Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: felix@jede.name.
  • Brandt T Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: theresa-brandt@gmx.net.
  • Gedefaw M Amhara Regional Health Bureau, Bahir Dar, Ethiopia. Electronic address: bdfam72@gmail.com.
  • Wubneh SB Department of Obstetrics and Gynecology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. Electronic address: solomonbe2310@gmail.com.
  • Abebe T Department of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. Electronic address: tamrat.abebe@aau.edu.et.
  • Teka B Department of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. Electronic address: brhanu.teka@aau.edu.et.
  • Alemu K Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. Electronic address: kassalemu@gmail.com.
  • Tilahun B Department of Health Informatics, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. Electronic address: binigcms@gmail.com.
  • Azemeraw T Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. Electronic address: tazemeraw@gmail.com.
  • Gebeyehu A Amhara Regional Health Bureau, Bahir Dar, Ethiopia. Electronic address: gabebaw2worku@gmail.com.
  • Schmidt D Department of Cytopathology, Institute of Pathology, Viersen, Germany. Electronic address: dischmi57@gmail.com.
  • Pesic A Clinic for Gynecology, Charité - Berlin Institute of Health, Charite - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany. Electronic address: aleksandra.pesic@charite.de.
  • Kaufmann AM Clinic for Gynecology, Charité - Berlin Institute of Health, Charite - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany. Electronic address: andreas.kaufmann@charite.de.
  • Abebe B Department of Pathology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. Electronic address: dischmi57@gmail.com.
  • Ayichew Z Department of Obstetrics and Gynecology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. Electronic address: zelalem538@yahoo.com.
  • Byczkowski M SAP SE, Walldorf, Germany. Electronic address: michael.byczkowski@sap.com.
  • Vaucher T École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Electronic address: timote.vaucher@epfl.ch.
  • Sartor H Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: heike.sartor@med.uni-heidelberg.de.
  • Andargie G Department of Health Systems and Policy, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. Electronic address: gashawab@gmail.com.
  • Bärnighausen T Heidelberg Institute of Global Health (HIGH), Faculty of Medicine and University Hospital, Heidelberg University, Heidelberg, Germany; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, USA; Africa Health Research Institute (AHRI), Somkhele and Durban, South Africa. Electronic address: till.baernighausen@uni-heidelberg.de.
  • von Knebel Doeberitz M Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: magnus.knebel-doeberitz@med.uni-heidelberg.de.
  • Bussmann H Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: Hermann.Bussmann@med.uni-heidelberg.de.
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  • 2020-05-17
Published in:
  • Papillomavirus research (Amsterdam, Netherlands). - 2020
Cervical cancer screening
Community
Electronic data system
Ethiopia
HPV testing
Home-based
Rural
Self-sampling
eHealth
p16/ki-67 dual stain cytology
English Primary HPV testing and triage of HPV-positive women is an effective cervical cancer screening strategy. Such a multi-visit screening algorithm is also promising for community-based screening in resource-poor communities, provided a robust tracking system is in place. A cervical cancer screening campaign was conducted in a rural community in Ethiopia. All women aged 25-65 years were offered genital self-sampling using the Evalyn Brush®. Samples were HPV-DNA-tested at a central laboratory. Key indicators were captured on tablet computers and linked by a cloud-based information system. HPV-positive women were examined at the local clinic using portable colposcopy, p16/Ki-67 dual stain cytology and biopsy examination. CIN2+ women were referred for LEEP to the referral hospital. Of 749 enumerated age-eligible women 634 (85%, (95% CI 82-88)) consented to screening, 429 samples were adequate for HPV testing, giving a total testing coverage of 57% (95% CI 53-62). The hrHPV prevalence was 14% (95% CI 5-22), 72% (95% CI 60-84) attended the clinic for a triage examination. Home-based HPV-DNA self-sampling and clinic-based triage assisted by cloud-based information technology is feasible in rural Ethiopia. Key components of such strategy are broad community awareness, high competency of community workers, and establishment of an adequate self-sampling and HPV-DNA testing platform.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/22156
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