Journal article
Preoperative clonidine attenuates stress response during emergence from anesthesia.
- Zalunardo MP Institute of Anesthesiology, University Hospital Zürich, Zürich, Switzerland. marco.zalunardo@ifa.usz.ch
- Zollinger A
- Spahn DR
- Seifert B
- Pasch T
- 2000-10-12
Published in:
- Journal of clinical anesthesia. - 2000
Adolescent
Adrenergic alpha-Agonists
Adult
Aged
Anesthesia, Inhalation
Blood Pressure
Cardiac Output
Catecholamines
Clonidine
Double-Blind Method
Female
Heart Rate
Hemodynamics
Humans
Intubation, Intratracheal
Male
Middle Aged
Preanesthetic Medication
Stress, Physiological
Sympathetic Nervous System
English
STUDY OBJECTIVES
To investigate whether a single preoperative IV dose of clonidine blunts the hemodynamic and hyperadrenergic responses not only to intubation, but also to extubation.
DESIGN
Randomized, double-blind, placebo-controlled study.
PATIENTS
29 ASA physical status I and II patients (ages 18-65) who were scheduled for noncardiac, elective surgery. Patients were randomly assigned to either receive clonidine 3 microg/kg IV immediately before anesthesia induction or placebo.
INTERVENTIONS
Insertion of a 14 G cannula in a large cubital vein for the determination of plasma catecholamines using local anesthesia. Insertion of a radial artery catheter for measuring blood pressure (BP) using local anesthesia. Transthoracic echocardiography to determine cardiac output (CO).
MEASUREMENTS
Heart rate (HR), mean arterial pressure (MAP), CO, and plasma catecholamine concentrations. Measurements were performed: before induction (baseline), during intubation, 10 min after intubation, after surgery, during extubation, and 10 min after extubation.
MAIN RESULTS
During intubation MAP, HR, and CO were lower in the clonidine group. Compared with baseline measurements, MAP and CO increased less in the clonidine group during intubation. During extubation, MAP was lower in the clonidine group. CO and MAP increased less as compared with baseline measurements in the clonidine group. Compared with the measurements after surgery CO less in the clonidine group during extubation (p < 0.05 for all results).
CONCLUSIONS
A single preoperative IV dose of clonidine (3 microg/kg) blunts the hemodynamic responses due to extubation in noncardiac surgery of intermediate duration.
To investigate whether a single preoperative IV dose of clonidine blunts the hemodynamic and hyperadrenergic responses not only to intubation, but also to extubation.
DESIGN
Randomized, double-blind, placebo-controlled study.
PATIENTS
29 ASA physical status I and II patients (ages 18-65) who were scheduled for noncardiac, elective surgery. Patients were randomly assigned to either receive clonidine 3 microg/kg IV immediately before anesthesia induction or placebo.
INTERVENTIONS
Insertion of a 14 G cannula in a large cubital vein for the determination of plasma catecholamines using local anesthesia. Insertion of a radial artery catheter for measuring blood pressure (BP) using local anesthesia. Transthoracic echocardiography to determine cardiac output (CO).
MEASUREMENTS
Heart rate (HR), mean arterial pressure (MAP), CO, and plasma catecholamine concentrations. Measurements were performed: before induction (baseline), during intubation, 10 min after intubation, after surgery, during extubation, and 10 min after extubation.
MAIN RESULTS
During intubation MAP, HR, and CO were lower in the clonidine group. Compared with baseline measurements, MAP and CO increased less in the clonidine group during intubation. During extubation, MAP was lower in the clonidine group. CO and MAP increased less as compared with baseline measurements in the clonidine group. Compared with the measurements after surgery CO less in the clonidine group during extubation (p < 0.05 for all results).
CONCLUSIONS
A single preoperative IV dose of clonidine (3 microg/kg) blunts the hemodynamic responses due to extubation in noncardiac surgery of intermediate duration.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/s0952-8180(00)00167-7
- PMID 11025232
- Persistent URL
- https://folia.unifr.ch/global/documents/219083
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