Silk fibroin as biomaterial for bone tissue engineering.
- Melke J Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands; Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands. Electronic address: j.melke@tue.nl.
- Midha S Department of Textile Technology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India. Electronic address: swati.mid@gmail.com.
- Ghosh S Department of Textile Technology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India. Electronic address: sghosh08@textile.iitd.ac.in.
- Ito K Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands; Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands; Department of Orthopaedics, UMC Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands. Electronic address: K.Ito@tue.nl.
- Hofmann S Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands; Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands; ETH Zurich, Institute for Biomechanics, Vladimir-Prelog-Weg 3, HCI E355.1, CH-8093 Zurich, Switzerland. Electronic address: S.Hofmann.Boss@tue.nl.
- 2015-09-12
Published in:
- Acta biomaterialia. - 2016
Bone tissue engineering
Drug delivery
Regenerative medicine
Scaffold
Silk fibroin
Animals
Biocompatible Materials
Bioprinting
Bombyx
Bone and Bones
Coculture Techniques
Drug Delivery Systems
Fibroins
Humans
Hydrogels
Osteogenesis
Printing, Three-Dimensional
Recombinant Proteins
Regenerative Medicine
Tissue Engineering
English
UNLABELLED
Silk fibroin (SF) is a fibrous protein which is produced mainly by silkworms and spiders. Its unique mechanical properties, tunable biodegradation rate and the ability to support the differentiation of mesenchymal stem cells along the osteogenic lineage, have made SF a favorable scaffold material for bone tissue engineering. SF can be processed into various scaffold forms, combined synergistically with other biomaterials to form composites and chemically modified, which provides an impressive toolbox and allows SF scaffolds to be tailored to specific applications. This review discusses and summarizes recent advancements in processing SF, focusing on different fabrication and functionalization methods and their application to grow bone tissue in vitro and in vivo. Potential areas for future research, current challenges, uncertainties and gaps in knowledge are highlighted.
STATEMENT OF SIGNIFICANCE
Silk fibroin is a natural biomaterial with remarkable biomedical and mechanical properties which make it favorable for a broad range of bone tissue engineering applications. It can be processed into different scaffold forms, combined synergistically with other biomaterials to form composites and chemically modified which provides a unique toolbox and allows silk fibroin scaffolds to be tailored to specific applications. This review discusses and summarizes recent advancements in processing silk fibroin, focusing on different fabrication and functionalization methods and their application to grow bone tissue in vitro and in vivo. Potential areas for future research, current challenges, uncertainties and gaps in knowledge are highlighted.
Silk fibroin (SF) is a fibrous protein which is produced mainly by silkworms and spiders. Its unique mechanical properties, tunable biodegradation rate and the ability to support the differentiation of mesenchymal stem cells along the osteogenic lineage, have made SF a favorable scaffold material for bone tissue engineering. SF can be processed into various scaffold forms, combined synergistically with other biomaterials to form composites and chemically modified, which provides an impressive toolbox and allows SF scaffolds to be tailored to specific applications. This review discusses and summarizes recent advancements in processing SF, focusing on different fabrication and functionalization methods and their application to grow bone tissue in vitro and in vivo. Potential areas for future research, current challenges, uncertainties and gaps in knowledge are highlighted.
STATEMENT OF SIGNIFICANCE
Silk fibroin is a natural biomaterial with remarkable biomedical and mechanical properties which make it favorable for a broad range of bone tissue engineering applications. It can be processed into different scaffold forms, combined synergistically with other biomaterials to form composites and chemically modified which provides a unique toolbox and allows silk fibroin scaffolds to be tailored to specific applications. This review discusses and summarizes recent advancements in processing silk fibroin, focusing on different fabrication and functionalization methods and their application to grow bone tissue in vitro and in vivo. Potential areas for future research, current challenges, uncertainties and gaps in knowledge are highlighted.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1016/j.actbio.2015.09.005
- PMID 26360593
- Persistent URL
- https://folia.unifr.ch/global/documents/217593
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