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N-oxide alkaloids from Crinum amabile (Amaryllidaceae).

  • Tallini LR Group of Natural Products, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, 27-31, 08028-Barcelona, Spain. lucianatallini@gmail.com.
  • Torras-Claveria L Group of Natural Products, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, 27-31, 08028-Barcelona, Spain. lauratorras@hotmail.com.
  • Borges WS Department of Chemistry, Federal University of Espírito Santo, Av. Fernando Ferrari 514, 29075-915 Vitoria ES, Brazil. warley000@yahoo.com.br.
  • Kaiser M Medicinal Parasitology and Infection Biology, Swiss Tropical Institure, Socinstrasse 57, 4051 Basel, Switzerland. marcel.kaiser@unibas.ch.
  • Viladomat F Group of Natural Products, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, 27-31, 08028-Barcelona, Spain. fviladomat@ub.edu.
  • Zuanazzi JAS Faculty of Pharmacy, Federal University of Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre RS, Brazil. zuanazzi@ufrgs.br.
  • Bastida J Group of Natural Products, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, 27-31, 08028-Barcelona, Spain. jaumebastida@ub.edu.
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  • 2018-06-05
Published in:
  • Molecules (Basel, Switzerland). - 2018
Crinum amabile
augustine N-oxide
biological activities
buphanisine N-oxide
Alkaloids
Amaryllidaceae Alkaloids
Antiprotozoal Agents
Cholinesterase Inhibitors
Crinum
Gas Chromatography-Mass Spectrometry
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Molecular Structure
Oxides
Phytochemicals
Plant Extracts
English Natural products play an important role in the development of new drugs. In this context, the Amaryllidaceae alkaloids have attracted considerable attention in view of their unique structural features and various biological activities. In this study, twenty-three alkaloids were identified from Crinum amabile by GC-MS and two new structures (augustine N-oxide and buphanisine N-oxide) were structurally elucidated by NMR. Anti-parasitic and cholinesterase (AChE and BuChE) inhibitory activities of six alkaloids isolated from this species, including the two new compounds, are described herein. None of the alkaloids isolated from C. amabile gave better results than the reference drugs, so it was possible to conclude that the N-oxide group does not increase their therapeutic potential.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/216974
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