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Palladium-Catalyzed Functionalization of Olefins and Alkynes: From Oxyalkynylation to Tethered Dynamic Kinetic Asymmetric Transformations (DYKAT)
Journal article

Palladium-Catalyzed Functionalization of Olefins and Alkynes: From Oxyalkynylation to Tethered Dynamic Kinetic Asymmetric Transformations (DYKAT)

  • Nicolai, Stefano Ecole Polytechnique Federale de Lausanne, SB-ISIC-LCSO, Lausanne, Switzerland
  • Orcel, Ugo Ecole Polytechnique Federale de Lausanne, SB-ISIC-LCSO, Lausanne, Switzerland
  • Muriel, Bastian Ecole Polytechnique Federale de Lausanne, SB-ISIC-LCSO, Lausanne, Switzerland
  • Greenwood, Phillip D. G. Ecole Polytechnique Federale de Lausanne, SB-ISIC-LCSO, Lausanne, Switzerland
  • Buzzetti, Luca Ecole Polytechnique Federale de Lausanne, SB-ISIC-LCSO, Lausanne, Switzerland
  • Purins, Mikus Ecole Polytechnique Federale de Lausanne, SB-ISIC-LCSO, Lausanne, Switzerland
  • Waser, Jerome ORCID Ecole Polytechnique Federale de Lausanne, SB-ISIC-LCSO, Lausanne, Switzerland
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  • 2020-11-10
Published in:
  • Synlett. - Georg Thieme Verlag KG. - 2020
Organic Chemistry
English In this review, an account about the palladium-catalyzed functionalization of alkenes and alkynes developed at the Laboratory of Catalysis and Organic Synthesis (LCSO) is presented. Starting from the intramolecular oxy- and amino-alkynylation of alkenes, tethered methods were then developed to functionalize allylic amines and alcohols, as well as propargylic amines. Finally, a new Dynamic Kinetic Asymmetric Transformation (DYKAT) was developed based on the use of a "one-arm" Trost-type ligand, giving access to enantiopure amino alcohols. Each section is a personal account of the researcher(s) who performed the work.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/214938
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