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Bangladeshi children with acute diarrhoea show faecal microbiomes with increased Streptococcus abundance, irrespective of diarrhoea aetiology.

  • Kieser S Gut Ecosystem Department, Institute of Nutritional Science, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000, Lausanne 26, Switzerland.
  • Sarker SA International Centre for Diarrheal Diseases Research, Bangladesh (icddr,b), Nutrition and Clinical Services Division, 68 Shaheed Tajuddin Ahmed Sharani, Mohakhali, Dhaka 1212, Bangladesh.
  • Sakwinska O Gut Ecosystem Department, Institute of Nutritional Science, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000, Lausanne 26, Switzerland.
  • Foata F Gut Ecosystem Department, Institute of Nutritional Science, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000, Lausanne 26, Switzerland.
  • Sultana S International Centre for Diarrheal Diseases Research, Bangladesh (icddr,b), Nutrition and Clinical Services Division, 68 Shaheed Tajuddin Ahmed Sharani, Mohakhali, Dhaka 1212, Bangladesh.
  • Khan Z International Centre for Diarrheal Diseases Research, Bangladesh (icddr,b), Nutrition and Clinical Services Division, 68 Shaheed Tajuddin Ahmed Sharani, Mohakhali, Dhaka 1212, Bangladesh.
  • Islam S International Centre for Diarrheal Diseases Research, Bangladesh (icddr,b), Nutrition and Clinical Services Division, 68 Shaheed Tajuddin Ahmed Sharani, Mohakhali, Dhaka 1212, Bangladesh.
  • Porta N Gut Ecosystem Department, Institute of Nutritional Science, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000, Lausanne 26, Switzerland.
  • Combremont S Gut Ecosystem Department, Institute of Nutritional Science, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000, Lausanne 26, Switzerland.
  • Betrisey B Nestlé Institute of Health Sciences, EPFL Innovation Park, CH-1015, Lausanne, Switzerland.
  • Fournier C Nestlé Institute of Health Sciences, EPFL Innovation Park, CH-1015, Lausanne, Switzerland.
  • Charpagne A Nestlé Institute of Health Sciences, EPFL Innovation Park, CH-1015, Lausanne, Switzerland.
  • Descombes P Nestlé Institute of Health Sciences, EPFL Innovation Park, CH-1015, Lausanne, Switzerland.
  • Mercenier A Gut Ecosystem Department, Institute of Nutritional Science, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000, Lausanne 26, Switzerland.
  • Berger B Gut Ecosystem Department, Institute of Nutritional Science, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000, Lausanne 26, Switzerland.
  • Brüssow H Gut Ecosystem Department, Institute of Nutritional Science, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000, Lausanne 26, Switzerland.
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  • 2018-05-23
Published in:
  • Environmental microbiology. - 2018
Bangladesh
Case-Control Studies
Child, Preschool
Diarrhea
Feces
Female
Humans
Infant
Male
Microbiota
Streptococcus
Virulence
English We report streptococcal dysbiosis in acute diarrhoea irrespective of aetiology. Compared with 20 healthy local controls, 71 Bangladeshi children hospitalized with acute diarrhoea (AD) of viral, mixed viral/bacterial, bacterial and unknown aetiology showed a significantly decreased bacterial diversity with loss of pathways characteristic for the healthy distal colon microbiome (mannan degradation, methylerythritol phosphate and thiamin biosynthesis), an increased proportion of faecal streptococci belonging to the Streptococcus bovis and Streptococcus salivarius species complexes, and an increased level of E. coli-associated virulence genes. No enteropathogens could be attributed to a subgroup of patients. Elevated lytic coliphage DNA was detected in 2 out of 5 investigated enteroaggregative E. coli (EAEC)-infected patients. Streptococcal outgrowth in AD is discussed as a potential nutrient-driven consequence of glucose provided with oral rehydration solution.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/214751
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