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Regulation of cGAS- and RLR-mediated immunity to nucleic acids.
Journal article

Regulation of cGAS- and RLR-mediated immunity to nucleic acids.

  • Ablasser A Global Health Institute, Swiss Federal Institute of Technology, Lausanne, Switzerland. andrea.ablasser@epfl.ch.
  • Hur S Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. sun.hur@childrens.harvard.edu.
  • 2019-12-11
Published in:
  • Nature immunology. - 2020
Adaptor Proteins, Signal Transducing
DEAD Box Protein 58
DNA
Host-Pathogen Interactions
Humans
Immunity, Innate
Membrane Proteins
Nucleotidyltransferases
RNA
Signal Transduction
English Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the structural similarity between those and host nucleic acids, mammalian cells have been able to evolve powerful innate immune signaling pathways that originate from the detection of cytosolic nucleic acid species, one of the most prominent being the cGAS-STING pathway for DNA and the RLR-MAVS pathway for RNA, respectively. Recent advances have revealed a plethora of regulatory mechanisms that are crucial for balancing the activity of nucleic acid sensors for the maintenance of overall cellular homeostasis. Elucidation of the various mechanisms that enable cells to maintain control over the activity of cytosolic nucleic acid sensors has provided new insight into the pathology of human diseases and, at the same time, offers a rich and largely unexplored source for new therapeutic targets. This Review addresses the emerging literature on regulation of the sensing of cytosolic DNA and RNA via cGAS and RLRs.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/212648
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