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Anticancer Organometallic Osmium(II)-p-cymene Complexes.
Journal article

Anticancer Organometallic Osmium(II)-p-cymene Complexes.

  • Păunescu E Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne (Switzerland).
  • Nowak-Sliwinska P Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne (Switzerland).
  • Clavel CM Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne (Switzerland).
  • Scopelliti R Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne (Switzerland).
  • Griffioen AW Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, 1081 HV Amsterdam (The Netherlands).
  • Dyson PJ Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne (Switzerland). paul.dyson@epfl.ch.
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  • 2015-07-21
Published in:
  • ChemMedChem. - 2015
antitumor agents
bioorganometallic chemistry
chorioallantoic membrane model
osmium complexes
Animals
Antineoplastic Agents
Apoptosis
Cell Line, Tumor
Chemistry Techniques, Synthetic
Chick Embryo
Chorioallantoic Membrane
Crystallography, X-Ray
Cymenes
Drug Screening Assays, Antitumor
Endothelial Cells
HEK293 Cells
Humans
Monoterpenes
Organometallic Compounds
Osmium Compounds
Ruthenium
English Osmium compounds are attracting increasing attention as potential anticancer drugs. In this context, a series of bifunctional organometallic osmium(II)-p-cymene complexes functionalized with alkyl or perfluoroalkyl groups were prepared and screened for their antiproliferative activity. Three compounds from the series display selectivity toward cancer cells, with moderate cytotoxicity observed against human ovarian carcinoma (A2780) cells, whereas no cytotoxicity was observed on non-cancerous human embryonic kidney (HEK-293) cells and human endothelial (ECRF24) cells. Two of these three cancer-cell-selective compounds induce cell death largely via apoptosis and were also found to disrupt vascularization in the chicken embryo chorioallantoic membrane (CAM) model. Based on these promising properties, these compounds have potential clinical applications.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/212425
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