Design of protein-protein interaction inhibitors based on protein epitope mimetics.
- Robinson JA Chemistry Department, University of Zürich, Switzerland. robinson@oci.unizh.ch
- 2009-03-07
Published in:
- Chembiochem : a European journal of chemical biology. - 2009
Animals
Biomimetic Materials
Biomimetics
Drug Design
Epitopes
Models, Molecular
Protein Binding
Protein Conformation
Proteins
Scorpion Venoms
Tumor Suppressor Protein p53
English
On the scaffold: Grafting protein epitopes onto conformationally designed scaffolds represents a very promising approach to protein ligand design, with potential applications in many areas of chemical biology and molecular medicine. The highlighted article describes the design and anticancer activity of novel p53/MDM2 inhibitors built upon a scorpion toxin scaffold. Other approaches to protein epitope mimetics are also briefly discussed.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1002/cbic.200900055
- PMID 19266524
- Persistent URL
- https://folia.unifr.ch/global/documents/210911
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