Journal article

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

  • Théry C Institut Curie, INSERM U932, PSL Research University, Paris, France.
  • Witwer KW The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA.
  • Aikawa E Brigham and Women's Hospital, Center for Interdisciplinary Cardiovascular Sciences, Boston, MA, USA.
  • Alcaraz MJ Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM), University of Valencia, Polytechnic University of Valencia, Valencia, Spain.
  • Anderson JD University of California, Davis, Department of Otolaryngology, Davis, CA, USA.
  • Andriantsitohaina R INSERM U1063, Université d'Angers, CHU d'Angers, Angers, France.
  • Antoniou A German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.
  • Arab T Université de Lille, INSERM, U-1192, Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse - PRISM, Lille, France.
  • Archer F University of Lyon, INRA, EPHE, UMR754 Viral Infections and Comparative Pathology, Lyon, France.
  • Atkin-Smith GK La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
  • Ayre DC Atlantic Cancer Research Institute, Moncton, Canada.
  • Bach JM Université Bretagne Loire, Oniris, INRA, IECM, Nantes, France.
  • Bachurski D University of Cologne, Department of Internal Medicine I, Cologne, Germany.
  • Baharvand H Royan Institute for Stem Cell Biology and Technology, ACECR, Cell Science Research Center, Department of Stem Cells and Developmental Biology, Tehran, Iran.
  • Balaj L Massachusetts General Hospital, Department of Neurosurgery, Boston, MA, USA.
  • Baldacchino S University of Malta, Department of Pathology, Msida, Malta.
  • Bauer NN University of South Alabama, Department of Pharmacology, Center for Lung Biology, Mobile, AL, USA.
  • Baxter AA La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
  • Bebawy M University of Technology Sydney, Discipline of Pharmacy, Graduate School of Health, Sydney, Australia.
  • Beckham C University of Rochester, Rochester, NY, USA.
  • Bedina Zavec A National Institute of Chemistry, Department of Molecular Biology and Nanobiotechnology, Ljubljana, Slovenia.
  • Benmoussa A Université Laval, Centre de Recherche du CHU de Québec, Department of Infectious Diseases and Immunity, Quebec City, Canada.
  • Berardi AC Ospedale Santo Spirito, Pescara, Italy.
  • Bergese P CSGI - Research Center for Colloids and Nanoscience, Florence, Italy.
  • Bielska E University of Birmingham, Institute of Microbiology and Infection, Birmingham, UK.
  • Blenkiron C University of Auckland, Auckland, New Zealand.
  • Bobis-Wozowicz S Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.
  • Boilard E Université Laval, Centre de Recherche du CHU de Québec, Department of Infectious Diseases and Immunity, Quebec City, Canada.
  • Boireau W FEMTO-ST Institute, UBFC, CNRS, ENSMM, UTBM, Besançon, France.
  • Bongiovanni A Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR) of Italy, Palermo, Italy.
  • Borràs FE Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, REMAR-IVECAT Group, Badalona, Spain.
  • Bosch S Université Bretagne Loire, Oniris, INRA, IECM, Nantes, France.
  • Boulanger CM INSERM UMR-S 970, Paris Cardiovascular Research Center, Paris, France.
  • Breakefield X Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Department of Neurology and Radiology, Boston, MA, USA.
  • Breglio AM Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
  • Brennan MÁ Harvard University, School of Engineering and Applied Sciences, Cambridge, MA, USA.
  • Brigstock DR Nationwide Children's Hospital, Columbus, OH, USA.
  • Brisson A UMR-CBMN, CNRS-Université de Bordeaux, Bordeaux, France.
  • Broekman ML Haaglanden Medical Center, Department of Neurosurgery, The Hague, The Netherlands.
  • Bromberg JF Memorial Sloan Kettering Cancer Center, Department of Medicine, New York City, NY, USA.
  • Bryl-Górecka P Lund University, Department of Cardiology, Lund, Sweden.
  • Buch S University of Nebraska Medical Center, Department of Pharmacology and Experimental Neuroscience, Omaha, NE, USA.
  • Buck AH University of Edinburgh, Institute of Immunology & Infection Research, Edinburgh, UK.
  • Burger D Kidney Research Centre, Ottawa, Canada.
  • Busatto S Mayo Clinic, Department of Transplantation, Jacksonville, FL, USA.
  • Buschmann D Technical University of Munich, TUM School of Life Sciences Weihenstephan, Division of Animal Physiology and Immunology, Freising, Germany.
  • Bussolati B University of Torino, Department of Molecular Biotechnology and Health Sciences, Torino, Italy.
  • Buzás EI MTA-SE Immuno-Proteogenomics Research Groups, Budapest, Hungary.
  • Byrd JB University of Michigan, Department of Medicine, Ann Arbor, MI, USA.
  • Camussi G University of Torino, Department of Medical Sciences, Torino, Italy.
  • Carter DR Oxford Brookes University, Department of Biological and Medical Sciences, Oxford, UK.
  • Caruso S La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
  • Chamley LW University of Auckland, Department of Obstetrics and Gynaecology, Auckland, New Zealand.
  • Chang YT National Taiwan University Hospital, Department of Internal Medicine, Taipei, Taiwan.
  • Chen C National Tsing Hua University, Department of Power Mechanical Engineering, Hsinchu, Taiwan.
  • Chen S Leibniz Institute for Farm Animal Biology (FBN), Institute of Reproductive Biology, Dummerstorf, Germany.
  • Cheng L La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
  • Chin AR Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Clayton A Cardiff University, School of Medicine, Cardiff, UK.
  • Clerici SP UNICAMP, Institute of Biology, Campinas, Brazil.
  • Cocks A Cardiff University, School of Medicine, Cardiff, UK.
  • Cocucci E The Ohio State University, College of Pharmacy, Division of Pharmaceutics and Pharmaceutical Chemistry, Columbus, OH, USA.
  • Coffey RJ Vanderbilt University Medical Center, Epithelial Biology Center, Department of Medicine, Nashville, TN, USA.
  • Cordeiro-da-Silva A University of Porto, Faculty of Pharmacy (FFUP), IBMC/I3S, Porto, Portugal.
  • Couch Y University of Oxford, Radcliffe Department of Medicine, Acute Stroke Programme - Investigative Medicine, Oxford, UK.
  • Coumans FA Academic Medical Centre of the University of Amsterdam, Department of Clinical Chemistry and Vesicle Observation Centre, Amsterdam, The Netherlands.
  • Coyle B The University of Nottingham, School of Medicine, Children's Brain Tumour Research Centre, Nottingham, UK.
  • Crescitelli R University of Gothenburg, Institute of Medicine at Sahlgrenska Academy, Krefting Research Centre, Gothenburg, Sweden.
  • Criado MF University of São Paulo, Ribeirão Preto Medical School, Ribeirão Preto, Brazil.
  • D'Souza-Schorey C University of Notre Dame, Department of Biological Sciences, Notre Dame, IN, USA.
  • Das S Massachusetts General Hospital, Boston, MA, USA.
  • Datta Chaudhuri A The Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA.
  • de Candia P IRCCS MultiMedica, Milan, Italy.
  • De Santana EF The Sociedade Beneficente Israelita Brasileira Albert Einstein, São Paulo, Brazil.
  • De Wever O Cancer Research Institute Ghent, Ghent, Belgium.
  • Del Portillo HA Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
  • Demaret T Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium.
  • Deville S Universiteit Hasselt, Diepenbeek, Belgium.
  • Devitt A Aston University, School of Life & Health Sciences, Birmingham, UK.
  • Dhondt B Cancer Research Institute Ghent, Ghent, Belgium.
  • Di Vizio D Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Dieterich LC ETH Zurich, Institute of Pharmaceutical Sciences, Zurich, Switzerland.
  • Dolo V University of L'Aquila, Department of Life, Health and Environmental Sciences, L'Aquila, Italy.
  • Dominguez Rubio AP Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Buenos Aires, Argentina.
  • Dominici M TPM of Mirandola, Mirandola, Italy.
  • Dourado MR University of Campinas, Piracicaba Dental School, Department of Oral Diagnosis, Piracicaba, Brazil.
  • Driedonks TA Utrecht University, Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht, The Netherlands.
  • Duarte FV Exogenus Therapeutics, Cantanhede, Portugal.
  • Duncan HM McGill University, Division of Experimental Medicine, Montreal, Canada.
  • Eichenberger RM James Cook University, Australian Institute of Tropical Health and Medicine, Centre for Biodiscovery and Molecular Development of Therapeutics, Cairns, Australia.
  • Ekström K University of Gothenburg, Institute of Clinical Sciences at Sahlgrenska Academy, Department of Biomaterials, Gothenburg, Sweden.
  • El Andaloussi S Evox Therapeutics Limited, Oxford, UK.
  • Elie-Caille C FEMTO-ST Institute, UBFC, CNRS, ENSMM, UTBM, Besançon, France.
  • Erdbrügger U University of Virginia Health System, Department of Medicine, Division of Nephrology, Charlottesville, VA, USA.
  • Falcón-Pérez JM CIC bioGUNE, CIBERehd, Exosomes Laboratory & Metabolomics Platform, Derio, Spain.
  • Fatima F University of São Paulo, Ribeirão Preto Medical School, Department of Pathology and Forensic Medicine, Ribeirão Preto, Brazil.
  • Fish JE Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
  • Flores-Bellver M University of Colorado, School of Medicine, Department of Ophthalmology, Cell Sight-Ocular Stem Cell and Regeneration Program, Aurora, CO, USA.
  • Försönits A Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary.
  • Frelet-Barrand A FEMTO-ST Institute, UBFC, CNRS, ENSMM, UTBM, Besançon, France.
  • Fricke F German Cancer Research Center (DKFZ), Clinical Cooperation Unit Applied Tumor Biology, Heidelberg, Germany.
  • Fuhrmann G Helmholtz-Centre for Infection Research, Braunschweig, Germany.
  • Gabrielsson S Karolinska Institute, Department of Medicine Solna, Division for Immunology and Allergy, Stockholm, Sweden.
  • Gámez-Valero A Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, REMAR-IVECAT Group, Badalona, Spain.
  • Gardiner C University College London, London, UK.
  • Gärtner K Helmholtz Center Munich German Research Center for Environmental Health, Research Unit Gene Vectors, Munich, Germany.
  • Gaudin R INSERM U1110, Strasbourg, France.
  • Gho YS POSTECH (Pohang University of Science and Technology), Department of Life Sciences, Pohang, South Korea.
  • Giebel B University Hospital Essen, University Duisburg-Essen, Institute for Transfusion Medicine, Essen, Germany.
  • Gilbert C Université Laval, Centre de Recherche du CHU de Québec, Department of Infectious Diseases and Immunity, Quebec City, Canada.
  • Gimona M Paracelsus Medical University, GMP Unit, Salzburg, Austria.
  • Giusti I University of L'Aquila, Department of Life, Health and Environmental Sciences, L'Aquila, Italy.
  • Goberdhan DC University of Oxford, Department of Physiology, Anatomy and Genetics, Oxford, UK.
  • Görgens A Evox Therapeutics Limited, Oxford, UK.
  • Gorski SM BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, Canada.
  • Greening DW La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
  • Gross JC University Medical Center Göttingen, Developmental Biochemistry, Göttingen, Germany.
  • Gualerzi A IRCCS Fondazione Don Carlo Gnocchi, Laboratory of Nanomedicine and Clinical Biophotonics (LABION), Milan, Italy.
  • Gupta GN Loyola University Chicago, Department of Urology, Maywood, IL, USA.
  • Gustafson D University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Canada.
  • Handberg A Aalborg University Hospital, Department of Clinical Biochemistry, Aalborg, Denmark.
  • Haraszti RA University of Massachusetts Medical School, RNA Therapeutics Institute, Worcester, MA, USA.
  • Harrison P University of Birmingham, Birmingham, UK.
  • Hegyesi H Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary.
  • Hendrix A Cancer Research Institute Ghent, Ghent, Belgium.
  • Hill AF La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
  • Hochberg FH Scintillon Institute, La Jolla, CA, USA.
  • Hoffmann KF Aberystwyth University, Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth, United Kingdom.
  • Holder B Imperial College London, London, UK.
  • Holthofer H University Clinic Eppendorf, Hamburg, Germany.
  • Hosseinkhani B Hasselt University, Biomedical Research Institute (BIOMED), Department of Medicine and Life Sciences, Hasselt, Belgium.
  • Hu G University of Nebraska Medical Center, Department of Pharmacology and Experimental Neuroscience, Omaha, NE, USA.
  • Huang Y Nanfang Hospital, Southern Medical University, Department of Clinical Laboratory Medicine, Guangzhou, China.
  • Huber V Fondazione IRCCS Istituto Nazionale dei Tumori, Unit of Immunotherapy of Human Tumors, Milan, Italy.
  • Hunt S The University of Sheffield, Sheffield, UK.
  • Ibrahim AG Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA.
  • Ikezu T Boston University School of Medicine, Boston, MA, USA.
  • Inal JM University of Hertfordshire, School of Life and Medical Sciences, Biosciences Research Group, Hatfield, UK.
  • Isin M Istanbul University Oncology Institute, Basic Oncology Department, Istanbul, Turkey.
  • Ivanova A German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany.
  • Jackson HK The University of Nottingham, School of Medicine, Children's Brain Tumour Research Centre, Nottingham, UK.
  • Jacobsen S Copenhagen Lupus and Vasculitis Clinic, Section 4242 - Rigshospitalet, Copenhagen, Denmark.
  • Jay SM University of Maryland, Fischell Department of Bioengineering, College Park, MD, USA.
  • Jayachandran M Mayo Clinic, College of Medicine, Department of Physiology and Biomedical Engineering, Rochester, MN, USA.
  • Jenster G Department of Urology, Rotterdam, The Netherlands.
  • Jiang L La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
  • Johnson SM University of Manchester, Division of Cancer Sciences, Manchester Cancer Research Centre, Manchester, UK.
  • Jones JC National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD, USA.
  • Jong A Children's Hospital of Los Angeles, Los Angeles, CA, USA.
  • Jovanovic-Talisman T City of Hope Comprehensive Cancer Center, Beckman Research Institute, Department of Molecular Medicine, Duarte, CA, USA.
  • Jung S German Research Center for Environmental Health, Institute for Virology, Munich, Germany.
  • Kalluri R University of Texas MD Anderson Cancer Center, Department of Cancer Biology, Metastasis Research Center, Houston, TX, USA.
  • Kano SI The Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD, USA.
  • Kaur S National Institutes of Health, National Cancer Institute, Center for Cancer Research, Laboratory of Pathology, Bethesda, MD, USA.
  • Kawamura Y National Cancer Center Research Institute, Tokyo, Japan.
  • Keller ET University of Michigan, Biointerfaces Institute, Ann Arbor, MI, USA.
  • Khamari D Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary.
  • Khomyakova E École normale supérieure, Paris, France.
  • Khvorova A University of Massachusetts Medical School, RNA Therapeutics Institute, Worcester, MA, USA.
  • Kierulf P Oslo University Hospital, Department of Medical Biochemistry, Blood Cell Research Group, Oslo, Norway.
  • Kim KP Kyung Hee University, Department of Applied Chemistry, Yongin, Korea.
  • Kislinger T Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
  • Klingeborn M Duke University, Department of Ophthalmology, Durham, NC, USA.
  • Klinke DJ West Virginia University, Department of Chemical and Biomedical Engineering and WVU Cancer Institute, Morgantown, WV, USA.
  • Kornek M German Armed Forces Central Hospital, Department of General, Visceral and Thoracic Surgery, Koblenz, Germany.
  • Kosanović MM University of Belgrade, Institute for the Application of Nuclear Energy, INEP, Belgrade, Serbia.
  • Kovács ÁF Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary.
  • Krämer-Albers EM University of Mainz, Institute of Developmental Biology and Neurobiology, Mainz, Germany.
  • Krasemann S University Medical Center Hamburg-Eppendorf, Institute of Neuropathology, Hamburg, Germany.
  • Krause M Hudson Institute of Medical Research, Melbourne, Australia.
  • Kurochkin IV Central Research Laboratories, Sysmex Co., Kobe, Japan.
  • Kusuma GD Hudson Institute of Medical Research, Melbourne, Australia.
  • Kuypers S Hasselt University, Biomedical Research Institute (BIOMED), Hasselt, Belgium.
  • Laitinen S Finnish Red Cross Blood Service, Research and Development, Helsinki, Finland.
  • Langevin SM Cincinnati Cancer Center, Cincinnati, OH, USA.
  • Languino LR Thomas Jefferson University, Sidney Kimmel Medical School, Department of Cancer Biology, Philadelphia, PA, USA.
  • Lannigan J University of Virginia, Flow Cytometry Core, School of Medicine, Charlottesville, VA, USA.
  • Lässer C University of Gothenburg, Institute of Medicine at Sahlgrenska Academy, Krefting Research Centre, Gothenburg, Sweden.
  • Laurent LC University of California, San Diego, Department of Obstetrics, Gynecology, and Reproductive Sciences, La Jolla, CA, USA.
  • Lavieu G Institut Curie, INSERM U932, PSL Research University, Paris, France.
  • Lázaro-Ibáñez E AstraZeneca, Discovery Sciences, IMED Biotech Unit, Gothenburg, Sweden.
  • Le Lay S INSERM U1063, Université d'Angers, CHU d'Angers, Angers, France.
  • Lee MS Eulji University, School of Medicine, Daejeon, South Korea.
  • Lee YXF Genome Institute of Singapore, ASTAR, Singapore.
  • Lemos DS Federal University of Paraná, Department of Genetics, Human Molecular Genetics Laboratory, Curitiba, Brazil.
  • Lenassi M University of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Ljubljana, Slovenia.
  • Leszczynska A University of California, San Diego, Department of Pediatrics, San Diego, CA, USA.
  • Li IT University of British Columbia Okanagan, Kelowna, Canada.
  • Liao K University of Nebraska Medical Center, Department of Pharmacology and Experimental Neuroscience, Omaha, NE, USA.
  • Libregts SF University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Department of Medicine, Cambridge NIHR BRC Cell Phenotyping Hub, Cambridge, UK.
  • Ligeti E Semmelweis University, Department of Physiology, Budapest, Hungary.
  • Lim R Hudson Institute of Medical Research, Melbourne, Australia.
  • Lim SK Institute of Medical Biology (IMB), Agency for Science and Technology (ASTAR), Singapore.
  • Linē A Latvian Biomedical Research and Study Centre, Riga, Latvia.
  • Linnemannstöns K University Medical Center Göttingen, Developmental Biochemistry, Göttingen, Germany.
  • Llorente A Oslo University Hospital-The Norwegian Radium Hospital, Institute for Cancer Research, Department of Molecular Cell Biology, Oslo, Norway.
  • Lombard CA Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium.
  • Lorenowicz MJ Utrecht University, University Medical Center Utrecht, Center for Molecular Medicine & Regenerative Medicine Center, Utrecht, The Netherlands.
  • Lörincz ÁM Semmelweis University, Department of Physiology, Budapest, Hungary.
  • Lötvall J University of Gothenburg, Institute of Medicine at Sahlgrenska Academy, Krefting Research Centre, Gothenburg, Sweden.
  • Lovett J Stellenbosch University, Department of Physiological Sciences, Stellenbosch, South Africa.
  • Lowry MC Trinity College Dublin, School of Pharmacy and Pharmaceutical Sciences, Panoz Institute & Trinity Biomedical Sciences Institute, Dublin, Ireland.
  • Loyer X INSERM UMR-S 970, Paris Cardiovascular Research Center, Paris, France.
  • Lu Q Harvard University, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Lukomska B Mossakowski Medical Research Centre, NeuroRepair Department, Warsaw, Poland.
  • Lunavat TR K.G. Jebsen Brain Tumor Research Centre, Department of Biomedicine, University of Bergen, Bergen, Norway.
  • Maas SL Utrecht University, University Medical Center Utrecht, Department of Neurosurgery, Brain Center Rudolf Magnus, Institute of Neurosciences, Utrecht, The Netherlands.
  • Malhi H Mayo Clinic, Rochester, MN, USA.
  • Marcilla A Universitat de València, Departament de Farmàcia i Tecnologia Farmacèutica i Parasitologia, Àrea de Parasitologia, Valencia, Spain.
  • Mariani J Università degli Studi di Milano, Department of Clinical Sciences and Community Health, EPIGET LAB, Milan, Italy.
  • Mariscal J Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Martens-Uzunova ES Department of Urology, Rotterdam, The Netherlands.
  • Martin-Jaular L Institut Curie, INSERM U932, PSL Research University, Paris, France.
  • Martinez MC INSERM U1063, Université d'Angers, CHU d'Angers, Angers, France.
  • Martins VR A.C.Camargo Cancer Center, São Paulo, Brazil.
  • Mathieu M Institut Curie, INSERM U932, PSL Research University, Paris, France.
  • Mathivanan S La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
  • Maugeri M University of Gothenburg, Sahlgrenska Academy, Department of Rheumatology and Inflammation Research, Gothenburg, Sweden.
  • McGinnis LK University of Southern California, Los Angeles, CA, USA.
  • McVey MJ SickKids Hospital, Department of Anesthesia and Pain Medicine, Toronto, Canada.
  • Meckes DG Florida State University College of Medicine, Department of Biomedical Sciences, Tallahassee, FL, USA.
  • Meehan KL The School of Biomedical Sciences, University of Western Australia, Perth, Australia.
  • Mertens I University of Antwerp, Centre for Proteomics, Antwerp, Belgium.
  • Minciacchi VR Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany.
  • Möller A QIMR Berghofer Medical Research Institute, Herston, Australia.
  • Møller Jørgensen M Aalborg University Hospital, Department of Clinical Immunology, Aalborg, Denmark.
  • Morales-Kastresana A National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD, USA.
  • Morhayim J Erasmus MC, Rotterdam, The Netherlands.
  • Mullier F Namur Thrombosis and Hemostasis Center (NTHC), NARILIS, Namur, Belgium.
  • Muraca M University of Padova, Department of Women's and Children's Health, Padova, Italy.
  • Musante L University of Virginia Health System, Department of Medicine, Division of Nephrology, Charlottesville, VA, USA.
  • Mussack V Technical University of Munich, TUM School of Life Sciences Weihenstephan, Division of Animal Physiology and Immunology, Freising, Germany.
  • Muth DC The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA.
  • Myburgh KH Stellenbosch University, Department of Physiological Sciences, Stellenbosch, South Africa.
  • Najrana T Brown University, Women and Infants Hospital, Providence, RI, USA.
  • Nawaz M University of Gothenburg, Sahlgrenska Academy, Department of Rheumatology and Inflammation Research, Gothenburg, Sweden.
  • Nazarenko I German Cancer Consortium (DKTK), Partner Site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Nejsum P Aarhus University, Department of Clinical Medicine, Aarhus, Denmark.
  • Neri C Sorbonne Université, Centre National de la Recherche Scientifique, Research Unit Biology of Adaptation and Aging (B2A), Team Compensation in Neurodegenerative and Aging (Brain-C), Paris, France.
  • Neri T University of Pisa, Centro Dipartimentale di Biologia Cellulare Cardio-Respiratoria, Pisa, Italy.
  • Nieuwland R Academic Medical Centre of the University of Amsterdam, Department of Clinical Chemistry and Vesicle Observation Centre, Amsterdam, The Netherlands.
  • Nimrichter L Universidade Federal do Rio de Janeiro, Instituto de Microbiologia, Rio de Janeiro, Brazil.
  • Nolan JP Scintillon Institute, La Jolla, CA, USA.
  • Nolte-'t Hoen EN Utrecht University, Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht, The Netherlands.
  • Noren Hooten N National Institutes of Health, National Institute on Aging, Baltimore, MD, USA.
  • O'Driscoll L Trinity College Dublin, School of Pharmacy and Pharmaceutical Sciences, Panoz Institute & Trinity Biomedical Sciences Institute, Dublin, Ireland.
  • O'Grady T University of Liège, GIGA-R(MBD), PSI Laboratory, Liège, Belgium.
  • O'Loghlen A Queen Mary University of London, Blizard Institute, Epigenetics & Cellular Senescence Group, London, UK.
  • Ochiya T National Cancer Center Research Institute, Division of Molecular and Cellular Medicine, Tokyo, Japan.
  • Olivier M McGill University, The Research Institute of the McGill University Health Centre, Montreal, Canada.
  • Ortiz A IIS-Fundacion Jimenez Diaz-UAM, Department of Nephrology and Hypertension, Madrid, Spain.
  • Ortiz LA Graduate School of Public Health at the University of Pittsburgh, Division of Occupational and Environmental Medicine, Pittsburgh, PA, USA.
  • Osteikoetxea X AstraZeneca, Discovery Sciences, IMED Biotech Unit, Cambridge, UK.
  • Østergaard O Statens Serum Institut, Department of Autoimmunology and Biomarkers, Copenhagen, Denmark.
  • Ostrowski M University of Buenos Aires, Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Buenos Aires, Argentina.
  • Park J POSTECH (Pohang University of Science and Technology), Department of Life Sciences, Pohang, South Korea.
  • Pegtel DM Amsterdam University Medical Centers, Department of Pathology, Amsterdam, The Netherlands.
  • Peinado H Spanish National Cancer Research Center (CNIO), Molecular Oncology Programme, Microenvironment and Metastasis Laboratory, Madrid, Spain.
  • Perut F IRCCS - Istituto Ortopedico Rizzoli, Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Bologna, Italy.
  • Pfaffl MW Technical University of Munich, TUM School of Life Sciences Weihenstephan, Division of Animal Physiology and Immunology, Freising, Germany.
  • Phinney DG The Scripps Research Institute-Scripps Florida, Department of Molecular Medicine, Jupiter, FL, USA.
  • Pieters BC Radboud University Medical Center, Department of Rheumatology, Nijmegen, The Netherlands.
  • Pink RC Oxford Brookes University, Department of Biological and Medical Sciences, Oxford, UK.
  • Pisetsky DS Duke University Medical Center, Departments of Medicine and Immunology, Durham, NC, USA.
  • Pogge von Strandmann E Philipps University Marburg, Experimental Tumor Biology, Marburg, Germany.
  • Polakovicova I Pontificia Universidad Católica de Chile, Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile.
  • Poon IK La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia.
  • Powell BH The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA.
  • Prada I CNR Institute of Neuroscience, Milan, Italy.
  • Pulliam L University of California, San Francisco, CA, USA.
  • Quesenberry P The Warren Alpert Medical School of Brown University, Department of Medicine, Providence, RI, USA.
  • Radeghieri A CSGI - Research Center for Colloids and Nanoscience, Florence, Italy.
  • Raffai RL Department of Veterans Affairs, San Francisco, CA, USA.
  • Raimondo S University of Palermo, Department of Biopathology and Medical Biotechnologies, Palermo, Italy.
  • Rak J McGill University, Montreal, Canada.
  • Ramirez MI Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Raposo G Institut Curie, CNRS UMR144, PSL Research University, Paris, France.
  • Rayyan MS University of Michigan Medical School, Ann Arbor, MI, USA.
  • Regev-Rudzki N Weizmann Institute of Science, Department of Biomolecular Sciences, Rehovot, Israel.
  • Ricklefs FL University Medical Center Hamburg-Eppendorf, Department of Neurosurgery, Hamburg, Germany.
  • Robbins PD University of Minnesota Medical School, Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, Minneapolis, MN, USA.
  • Roberts DD National Institutes of Health, National Cancer Institute, Center for Cancer Research, Laboratory of Pathology, Bethesda, MD, USA.
  • Rodrigues SC CNC, Coimbra, Portugal.
  • Rohde E Paracelsus Medical University, Department of Transfusion Medicine, Salzburg, Austria.
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  • 2019-01-15
Published in:
  • Journal of extracellular vesicles. - 2018
English The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
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  • English
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gold
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https://folia.unifr.ch/global/documents/209234
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