On pseudo-values for regression analysis in competing risks models.
- Graw F Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland. frederik.graw@env.ethz.ch
- Gerds TA
- Schumacher M
- 2008-12-04
Published in:
- Lifetime data analysis. - 2009
Arthroplasty, Replacement
Biometry
Humans
Kaplan-Meier Estimate
Models, Statistical
Regression Analysis
Risk
Survival Analysis
English
For regression on state and transition probabilities in multi-state models Andersen et al. (Biometrika 90:15-27, 2003) propose a technique based on jackknife pseudo-values. In this article we analyze the pseudo-values suggested for competing risks models and prove some conjectures regarding their asymptotics (Klein and Andersen, Biometrics 61:223-229, 2005). The key is a second order von Mises expansion of the Aalen-Johansen estimator which yields an appropriate representation of the pseudo-values. The method is illustrated with data from a clinical study on total joint replacement. In the application we consider for comparison the estimates obtained with the Fine and Gray approach (J Am Stat Assoc 94:496-509, 1999) and also time-dependent solutions of pseudo-value regression equations.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1007/s10985-008-9107-z
- PMID 19051013
- Persistent URL
- https://folia.unifr.ch/global/documents/207993
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