Back
Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology.
Journal article

Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology.

  • Borsari C Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • Trader DJ Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 610 Purdue Mall, West Lafayette, Indiana 47907, United States.
  • Tait A Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
  • Costi MP Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
Show more…
  • 2020-02-06
Published in:
  • Journal of medicinal chemistry. - 2020
Animals
Biological Products
Drug Delivery Systems
Drug Discovery
Humans
Pharmaceutical Preparations
Protein Structure, Secondary
English After the first seed concept introduced in the 18th century, different disciplines have attributed different names to dual-functional molecules depending on their application, including bioconjugates, bifunctional compounds, multitargeting molecules, chimeras, hybrids, engineered compounds. However, these engineered constructs share a general structure: a first component that targets a specific cell and a second component that exerts the pharmacological activity. A stable or cleavable linker connects the two modules of a chimera. Herein, we discuss the recent advances in the rapidly expanding field of chimeric molecules leveraging chemical biology concepts. This Perspective is focused on bifunctional compounds in which one component is a lead compound or a drug. In detail, we discuss chemical features of chimeric molecules and their use for targeted delivery and for target engagement studies.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/206801
Statistics
Document views: 8 File downloads: