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Electrically evoked compound action potentials are different depending on the site of cochlear stimulation.

  • van de Heyning P a Antwerp University Hospital , Antwerp , Belgium.
  • Arauz SL b Instituto de ORL , Buenos Aires , Argentina.
  • Atlas M c Ear Science Centre, School of Surgery , The University of Western Australia , Nedlands , Australia.
  • Baumgartner WD e Medizinische Universität Wien, Universitätsklinik für Hals-, Nasen- und Ohrenkrankheiten , Vienna , Austria.
  • Caversaccio M f Universitätsklinik für HNO, Kopf- und Halschirurgie, Inselspital Bern , Bern , Switzerland.
  • Chester-Browne R c Ear Science Centre, School of Surgery , The University of Western Australia , Nedlands , Australia.
  • Estienne P b Instituto de ORL , Buenos Aires , Argentina.
  • Gavilan J g Hospital Universitario La Paz, Institute for Health Research (IdiPAZ) , Madrid , Spain.
  • Godey B h Centre Hospitalier Universitaire de Rennes , Rennes , France.
  • Gstöttner W e Medizinische Universität Wien, Universitätsklinik für Hals-, Nasen- und Ohrenkrankheiten , Vienna , Austria.
  • Han D i Capital Medical University, Beijing Tongren Hospital , Beijing , China.
  • Hagen R j Klinik und Poliklinik für Hals-, Nasen und Ohren- Krankheiten , Universität Würzburg , Würzburg , Germany.
  • Kompis M f Universitätsklinik für HNO, Kopf- und Halschirurgie, Inselspital Bern , Bern , Switzerland.
  • Kuzovkov V k St. Petersburg ENT and Speech Research Institute , St. Petersburg , Russia.
  • Lassaletta L g Hospital Universitario La Paz, Institute for Health Research (IdiPAZ) , Madrid , Spain.
  • Lefevre F h Centre Hospitalier Universitaire de Rennes , Rennes , France.
  • Li Y i Capital Medical University, Beijing Tongren Hospital , Beijing , China.
  • Müller J l Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde , Klinikum der Universität München , München , Germany.
  • Parnes L m London Health Sciences Centre , London , Canada.
  • Kleine Punte A a Antwerp University Hospital , Antwerp , Belgium.
  • Raine C n Bradford Royal Infirmary , Bradford , United Kingdom.
  • Rajan G o Otolaryngology, Head & Neck Surgery Unit, School of Surgery , University of Western Australia, Fremantle Hospital , Fremantle , Australia.
  • Rivas A p Clinica Rivas, Centro Medico Otologico , Bogota , Colombia.
  • Rivas JA p Clinica Rivas, Centro Medico Otologico , Bogota , Colombia.
  • Royle N n Bradford Royal Infirmary , Bradford , United Kingdom.
  • Sprinzl G q Universitätsklinik für Hals- Nasen- Ohrenheilkunde Innsbruck , Innsbruck , Austria.
  • Stephan K r Universitätsklinik für Hör-, Stimm- und Sprachstörungen Innsbruck , Innsbruck , Austria.
  • Walkowiak A s Institute of Physiology and Pathology of Hearing , Warsaw , Poland.
  • Yanov Y k St. Petersburg ENT and Speech Research Institute , St. Petersburg , Russia.
  • Zimmermann K m London Health Sciences Centre , London , Canada.
  • Zorowka P r Universitätsklinik für Hör-, Stimm- und Sprachstörungen Innsbruck , Innsbruck , Austria.
  • Skarzynski H s Institute of Physiology and Pathology of Hearing , Warsaw , Poland.
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  • 2016-12-01
Published in:
  • Cochlear implants international. - 2016
ART
Amplitude
Apical
Basal
Cochlea
Cochlear implant
Double peak
ECAP
Electrode
Middle
Recovery sequence
Threshold
Action Potentials
Adult
Cochlea
Cochlear Implantation
Cochlear Implants
Electric Stimulation
Evoked Potentials, Auditory
Female
Hearing Loss, Sensorineural
Humans
Male
Prospective Studies
Treatment Outcome
English One of the many parameters that can affect cochlear implant (CI) users' performance is the site of presentation of electrical stimulation, from the CI, to the auditory nerve. Evoked compound action potential (ECAP) measurements are commonly used to verify nerve function by stimulating one electrode contact in the cochlea and recording the resulting action potentials on the other contacts of the electrode array. The present study aimed to determine if the ECAP amplitude differs between the apical, middle, and basal region of the cochlea, if double peak potentials were more likely in the apex than the basal region of the cochlea, and if there were differences in the ECAP threshold and recovery function across the cochlea. ECAP measurements were performed in the apical, middle, and basal region of the cochlea at fixed sites of stimulation with varying recording electrodes. One hundred and forty one adult subjects with severe to profound sensorineural hearing loss fitted with a Standard or FLEXSOFT electrode were included in this study. ECAP responses were captured using MAESTRO System Software (MED-EL). The ECAP amplitude, threshold, and slope were determined using amplitude growth sequences. The 50% recovery rate was assessed using independent single sequences that have two stimulation pulses (a masker and a probe pulse) separated by a variable inter-pulse interval. For all recordings, ECAP peaks were annotated semi-automatically. ECAP amplitudes were greater upon stimulation of the apical region compared to the basal region of the cochlea. ECAP slopes were steeper in the apical region compared to the basal region of the cochlea and ECAP thresholds were lower in the middle region compared to the basal region of the cochlea. The incidence of double peaks was greater upon stimulation of the apical region compared to the basal region of the cochlea. This data indicates that the site and intensity of cochlear stimulation affect ECAP properties.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/206401
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