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The story of HCC in NAFLD: from epidemiology, across pathogenesis, to prevention and treatment.

  • Margini C Hepatology, Department of Clinical Research, University of Bern, Bern, Switzerland.
  • Dufour JF Hepatology, Department of Clinical Research, University of Bern, Bern, Switzerland.
  • 2015-11-26
Published in:
  • Liver international : official journal of the International Association for the Study of the Liver. - 2016
HCC
NAFLD
diabetes
obesity
Animals
Carcinoma, Hepatocellular
Comorbidity
Humans
Incidence
Liver Cirrhosis
Liver Neoplasms
Non-alcoholic Fatty Liver Disease
Prognosis
Risk Assessment
Risk Factors
English Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. An increasing number of reports describe HCC in the setting of obesity and diabetes, two major risk factors for non-alcoholic fatty liver disease (NAFLD). The increasing incidence of these conditions and the emerging evidence of HCC in non-cirrhotic NAFLD prioritize a better understanding of NAFLD-related HCC epidemiology and pathogenesis in order to target screening policies and develop preventive-therapeutic strategies. In this review, we focus on the epidemiological impact of this condition, suggesting a possible link between HCC in cryptogenic cirrhosis and NAFLD. Furthermore, we analyse the suggested pathogenic mechanisms and the possible preventive-therapeutic strategies.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/206082
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